dc.contributor.author | Güney, Huri | |
dc.contributor.author | Caliskan, Canan | |
dc.contributor.author | Çelik, Samettin | |
dc.contributor.author | Yurtcu, Nazan | |
dc.contributor.author | Hatırnaz, Şafak | |
dc.contributor.author | Avcı, Bahattin | |
dc.contributor.author | Tinelli, Andrea | |
dc.date.accessioned | 2023-06-23T05:23:15Z | |
dc.date.available | 2023-06-23T05:23:15Z | |
dc.date.issued | 2022/6 | tr |
dc.identifier.citation | Güvey H, Soyer Çalışkan C, Çelik S, Yurtçu N, Hatırnaz Ş, Avcı B, Tinelli A. Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. Turk J Obstet Gynecol. 2022 Jun 27;19(2):104-110. doi: 10.4274/tjod.galenos.2022.25307. PMID: 35770490; PMCID: PMC9249367. | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14019 | |
dc.description.abstract | Abstract
Objective:
Preeclampsia is a highly morbid disease of placental origin, life-threatening condition for both a pregnant woman and her fetus. Cadherin 6 and 11 are adhesion molecules that play an important role in trophoblastic development and placentation. In our study, we investigated the change in serum cadherin 6 and 11 levels in pregnant women with preeclampsia.
Materials and Methods:
Pregnant women with preeclampsia were selected and compared with healthy women (as a control group) for a one-year study. The serum alanine aminotransferase, aspartate aminotransferase, and cadherin levels 6 and 11 of participants were analyzed and compared.
Results:
A total of 189 pregnant women were subdivided into 2 groups as preeclamptic (n=94) and women with healthy pregnancy (n=95). The cadherin 6 and cadherin 11 levels of the preeclamptic patients were significantly higher than those in the control group (p=0.001), and they were found to be significantly higher mainly in patients with early-onset and severe preeclampsia group (p=0.001). The cut-off cadherin 6 and 11 values for severe preeclampsia were found as 98.174 ng/mL and 1.92 ng/mL; with sensitivity of 88.3% and 84% respectively (p=0.001).
Conclusion:
The data analysis showed elevated serum cadherin 6 and 11 levels associated with the severity and early onset of pre-eclampsia. Serum cadherin 6 and 11 levels can be a candidate marker for the prediction of preeclampsia. | tr |
dc.language.iso | eng | tr |
dc.relation.isversionof | 10.4274/tjod.galenos.2022.25307 | tr |
dc.rights | info:eu-repo/semantics/closedAccess | tr |
dc.subject | Cadherin 6, cadherin 11, preeclampsia, severe preeclampsia, early-onset preeclampsia | tr |
dc.title | Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study | tr |
dc.type | article | tr |
dc.relation.journal | Turkish Journal of Obstetrics and Gynecology | tr |
dc.contributor.department | Tıp Fakültesi | tr |
dc.contributor.authorID | 0000-0003-4725-043X | tr |
dc.identifier.volume | 19 | tr |
dc.identifier.issue | 2 | tr |
dc.identifier.startpage | 104 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |