dc.contributor.author | Ekici, Mehmet | |
dc.date.accessioned | 2024-02-26T07:20:16Z | |
dc.date.available | 2024-02-26T07:20:16Z | |
dc.date.issued | 2023 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14299 | |
dc.description.abstract | Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates
the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on cyclophosphamide-induced liver injury.
Methods Twenty-eight Wistar albino rats were randomly divided into four groups (n = 7 per group): healthy rats, cyclophosphamide (200 mg/kg),
cyclophosphamide (200 mg/kg) + ASE (100 mg/kg) and cyclophosphamide (200 mg/kg) + ASE (200 mg/kg). ASE was administered for 14 days,
and the rats were euthanized 24 h after cyclophosphamide administration.
Key findings Cyclophosphamide treatment leads to an increase in serum levels of alanine aminotransferase, aspartate aminotransferase, lactate
dehydrogenase, total cholesterol, triglycerides, low-density lipoprotein and very low-density lipoprotein, as well as an increase in the liver
levels of malondialdehyde, tumour necrosis factor, interleukin (IL)-1β and IL-6, while high-density lipoprotein levels decrease. Treatment with
cyclophosphamide caused liver necrosis and postnecrotic cell infiltration; however, pathological changes were prevented by ASE. 8-Hydroxy-2ʹ-
deoxyguanosine, anti-4-hydroxynenal antibody and anti-dityrosine levels increased in rats treated with cyclophosphamide and decreased in the
groups treated with ASE. These changes were dose dependent in the ASE-treated groups.
Conclusions Treatment with cyclophosphamide caused liver damage due to oxidative stress and inflammation. ASE regulated the damage at
high doses because it has potent antioxidant and anti-inflammatory ingredients. In future studies, it may be beneficial to administer ASE in higher
doses or for longer periods of time. | tr |
dc.language.iso | eng | tr |
dc.publisher | Oxford University Press | tr |
dc.relation.isversionof | https://doi.org/10.1093/jpp/rgad002 | tr |
dc.rights | info:eu-repo/semantics/restrictedAccess | tr |
dc.subject | Allium scorodoprasum extract; cyclophosphamide; inflammation; liver toxicity; oxidative stress | tr |
dc.title | Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats | tr |
dc.type | article | tr |
dc.relation.journal | Journal of Pharmacy and Pharmacology | tr |
dc.contributor.department | Veteriner Fakültesi | tr |
dc.contributor.authorID | 0000-0002-2163-6214 | tr |
dc.identifier.volume | 75 | tr |
dc.identifier.issue | 5 | tr |
dc.identifier.endpage | 634 | tr |
dc.identifier.startpage | 625 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |