dc.contributor.author | Halef Okan Dogan | |
dc.date.accessioned | 2024-02-27T09:06:31Z | |
dc.date.available | 2024-02-27T09:06:31Z | |
dc.date.issued | 2023 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14359 | |
dc.description.abstract | Objectives: Our study aimed to investigate the role of
endoplasmic reticulum stress (ER) in brain damage following
hepatic ischemia-reperfusion (HIR) injury. Specifically, we
characterized the expression of markers of ER stress and
histopathologic changes in the brain following HIR.
Methods: Twelve adults female Wistar rats were divided
into two experimental groups equally. Group 1 was
designed as the control group, and Group 2 was designed
as the HIR group. Blood, liver, and brain tissue samples
were collected during the sacrifice. The quantitative
ELISA kits were used to detect glucose-regulated protein
78 (GRP-78), activating transcription factor 4 (ATF-4),
eukaryotic initiation factor 2 alpha (EIF2-A), caspase-3,
caspase-9, and CCAAT/enhancer-binding protein (CEBP) in
plasma. Histopathological examination was performed
for liver and brain tissues.Results: Higher levels of GRP-78 (p=0.006), ATF4 (p=0.001),
and EIF2-Α (p=0.007) were detected in group 2. More damage
was detected in liver and brain samples in the histopathological
examination of group 2 than in group 1.
Conclusions: Our results demonstrate that ER stress is
involved in developing brain damage following hepatic
ischemia-reperfusion injury, as evidenced by increased
expression of markers of ER stress and neuronal injury. | tr |
dc.language.iso | eng | tr |
dc.relation.isversionof | doi.org/10.1515/tjb-2022-0292 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.title | Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury | tr |
dc.type | article | tr |
dc.relation.journal | Turkish Journal of Biochemistry | tr |
dc.contributor.department | Sağlık Bilimleri Enstitüsü | tr |
dc.contributor.authorID | 0000-0001-8738-0760 | tr |
dc.identifier.volume | 48 | tr |
dc.identifier.issue | 4 | tr |
dc.identifier.endpage | 439 | tr |
dc.identifier.startpage | 432 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |