Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep
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Tarih
13/09/2023Yazar
Hüseyin GÜNGÖROrhan ÇORUM
Duygu Durna ÇORUM
Alper Serhat KUMRU
Gökhan YILMAZ
Devran COŞKUN
Alparslan COŞKUN
Kamil ÜNEY
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The aim of this study is to determine the pharmacokinetic change after intravenous
administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was
carried out on six Akkaraman sheep. Meloxicam was administered intravenously to
each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with
a 15-day washout period. Plasma concentrations of meloxicam were determined using
the high performance liquid chromatography-ultraviolet, and pharmacokinetic parameters
were evaluated by non-compartmental analysis. Meloxicam was detected up
to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose
increased from 0.5 to 2 mg/kg, terminal elimination half-life, and dose normalized area
under the concentration versus time curve increased and total clearance decreased.
Compared to the 1 mg/kg dose, it was determined that Vdss decreased and C0.083h
increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of
>0.39 μg/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses,
respectively. These results show that meloxicam exhibits non-linear pharmacokinetics
and will achieve unpredictable plasma concentrations when administered IV for a
rapid effect at dose of ≥1 mg/kg in sheep.