| dc.description.abstract | Cadmium is a major environmental pollutant and a highly toxic metal. It was aimed to
determine the effects of pomegranate peel extract (PPE), N-acetylcysteine (NAC) alone and along
with Ornipural on cadmium-induced toxicity. Forty-six Wistar Albino male rats were divided into
6 groups and the groups were formed into healthy control, Cadmium group (5 mg/kg/day, oral),
Cadmium + Pomegranate peel extract (500 mg/kg, oral), Cadmium + N-acetylcysteine (100 mg/kg,
oral), Cadmium + Pomegranate peel extract (500 mg/kg, oral) + Ornipural (1 mL/kg, subcutaneous)
and Cadmium + N-acetylcysteine (100 mg/kg, oral) + Ornipural (1 mL/kg, subcutaneous). Cadmium
accumulated heavily in both liver and kidney tissue. The administration of N-acetylcysteine
and pomegranate peel extract alone reduced cadmium levels in both tissues. N-acetylcysteine
treatment prevented the increase in ALT and MDA levels by cadmium damage. N-acetylcysteine +
Ornipural treatment inhibited the increase in liver 8-OHdG level in the liver. N-acetylcysteine and
N-acetylcysteine + Ornipural treatments prevented the reduced serum MMP2 level. N-acetylcysteine
and Pomegranate peel extract + Ornipural treatments significantly reduced the increased liver iNOS
level in the liver. In conclusion, NAC therapy may be a successful treatment option for cadmium
toxicity. However, further research is needed on the effects of PPE and Ornipural combinations for
the treatment of cadmium toxicity. In future studies, various doses of these treatment options (with
chelators) should be investigated for cadmium toxicity. | tr |
