The effects of low‑level laser therapy on polycystic ovarian syndrome in rats: three diferent dosages
Date
Ağustos 20Author
Polat, BülentOkur, Damla Tuğçe
Çolak, Armağan
Yılmaz, Kader
Özkaraca, Mustafa
Çomaklı, Selim
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The main objective of this in vivo study was to investigate the efect of diferent low-level laser therapy (LLLT) doses
on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol valerate (EV) was
administered to induce PCOS in female rats. After administration of the EV for induction of PCOS, rats were divided into 5
groups (n = 8/group): C group (animals that were not exposed to any form of procedure), PC group (no treatment following
EV induction), L1 group (1 J/cm2
LLLT treatment following EV induction), L2 group (2 J/cm2
LLLT treatment following
EV induction), L3 group (6 J/cm2
LLLT treatment following EV induction). The results indicated that no signifcant dif ference was found in the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone
(P4) between the C and L2 groups (p < 0.05). Although the serum levels of testosterone (T) were signifcantly higher in the
C group compared with other groups (p < 0.05), the L2 group was determined to be the closest to the C group. Additionally,
the LH, FSH, and T receptor level of the L2 group was closest to the C group. In conclusion, a 2 J/cm2
dosage of LLLT (L2
group) can be considered the most potentially efective treatment of PCOS in the rat. However, more studies are needed to
determine the optimal dose of LLLT for the treatment of PCOS.