dc.contributor.author | Arı, Erkan | |
dc.contributor.author | Şahin, Neslihan | |
dc.contributor.author | Üstün, Elvan | |
dc.contributor.author | Dündar, Muhammed | |
dc.contributor.author | Karcı, Hüseyin | |
dc.contributor.author | Özdemir, İlknur | |
dc.contributor.author | Koç, Ahmet | |
dc.contributor.author | Gürbüz, Nevin | |
dc.contributor.author | Özdemir, İsmail | |
dc.date.accessioned | 2024-03-06T06:14:59Z | |
dc.date.available | 2024-03-06T06:14:59Z | |
dc.date.issued | 2023 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14721 | |
dc.description.abstract | In this study, a series of N-functionalized benzimidazole silver(I) complexes were prepared and characterized by FT-IR, 1H,
13C{1H} NMR spectroscopy, and elemental analysis. Synthesized N-benzylbenzimidazole silver(I) complexes were evaluated
for their antimicrobial activities against bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus,
and the fungal strains Candida albicans and Candida glabrata. The results indicated that N-alkylbenzimidazole silver(I)
complexes exhibited good antimicrobial activity compared to N-alkylbenzimidazole derivatives. Especially, complex 2e
presented perfect antimicrobial activity than the other complexes. The characterized molecules were optimized by DFT-based
calculation methods and the optimized molecules were analyzed in detail by molecular docking methods against bacterial
DNA-gyrase and CYP51. The amino acid residues detected for both target molecules are consistent with expectations, and
the calculated binding affinities and inhibition constants are promising for further studies. | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.title | Synthesis, antimicrobial activity and molecular docking study of benzyl functionalized benzimidazole silver(I) complexes | tr |
dc.type | article | tr |
dc.contributor.department | Eğitim Bilimleri Enstitüsü | tr |
dc.relation.publicationcategory | Rapor | tr |