The Effect of Resveratrol on Live Weight, Serum Biochemistry and Tissue Antioxidant Enzymes in Rats

Abstract

The aim of this study is to determine the effects of resveratrol used in adding it todrinking water. The study was carried out with 24 Wistar albino male 20 days rats for40 days. The study design was determined as one control and two trial groups (eachgroup with 2 parallels and each parallel with 4 rats). The first group was given a basalration and drinking water. The second group was given the basal ration and drinkingwater with 10 mg/kg resveratrol; and the third group was given the basal ration anddrinking water 20 mg/kg resveratrol. In serum biochemistry parameters, significantdecreases were observed in serum Aspartate aminotransferase (AST) enzyme activity,blood urea nitrogen (BUN), albumin, total protein and globulin concentrations andincrease in albumin/globulin ratio in groups given resveratrol (p<0.05). Regardless ofthe dose, an increase in the concentration of glutathione (GSH) from the antioxidantparameters was observed in the liver; In the kidney, an increase was observed in theRes10 group. In addition, a decrease in muscle superoxide dismutase (SOD) activityand an increase in muscle and kidney catalase (CAT) activity were observed. A decreasewas observed in malondialdehyde (MDA) concentrations, which is a parameter of lipidperoxidation in the kidney. As a result, it was determined in the present study thatresveratrol has antioxidant effects regardless of the way of use, and it was concludedthat this additive can be used for various purposes.