dc.contributor.author | Kurt, Begüm | |
dc.contributor.author | Öksüz, Kerim Emre | |
dc.contributor.author | İnan, Zeynep Deniz Şahin | |
dc.contributor.author | Hepokur, Ceylan | |
dc.date.accessioned | 2024-03-07T08:28:58Z | |
dc.date.available | 2024-03-07T08:28:58Z | |
dc.date.issued | 15-04-2023 | tr |
dc.identifier.citation | Kurt B, Oksuz KE, Sahin-Inan ZD, Hepokur C. Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model. Cir Cir. 2023;91(4):457-467. English. doi: 10.24875/CIRU.23000097. PMID: 37677953. | tr |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/37677953/ | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14870 | |
dc.description.abstract | Objective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate (DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly adult, 60 Wistar albino rats were used as experimental animals. The modified rat uterine horn adhesion model was used to induce intra-abdominal adhesion. Tumor necrosis factor (TNF)-α, interleukin (IL)-1, vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β1 were studied for biochemical and immunohistochemical examination. Results: TNF-α decreased in each group, while it decreased more in G2 and G3 than in G1. IL-1β decreased in each group, while it decreased the most in G3. TGF-β1 and VEGF localization was less in the G2 compared to G1, the least TGF-β1 and VEGF immunolocalization was detected in the G3 and G4. For both antibodies, the least localization among all groups belonged to G3. From day 7 to day 21, the highest TGF-β1 immunolocalization was observed in G1, lesser localization in G2 and lowest in G3. Conclusion: DCPD nanoparticles show promise as a clinical antiadhesive agent and should be further evaluated in experimental animal models and human trials. | tr |
dc.language.iso | eng | tr |
dc.publisher | Mexican Academy of Surgery | tr |
dc.relation.isversionof | doi: 10.24875/CIRU.23000097 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | Dicalcium phosphate dihydrate. Gynecologic surgery. Nanoparticles. Wistar rats. | tr |
dc.title | Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model | tr |
dc.type | animation | tr |
dc.relation.journal | CIRUGIA Y CIRUJANOS | tr |
dc.contributor.department | Mühendislik Fakültesi | tr |
dc.contributor.authorID | 0000-0001-7424-5930 | tr |
dc.identifier.volume | 91 | tr |
dc.identifier.issue | 4 | tr |
dc.identifier.endpage | 467 | tr |
dc.identifier.startpage | 457 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |