| dc.description.abstract | Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized
with different spectroscopic techniques such as
1
HNMR,
13
CNMR,andHRMS.The
synthesized analogs were examined against α‐glucosidase and α‐amylase enzymes to
determine their antidiabetic potential. Compounds 5g and 5q showed the most activity
with 35.04 ± 1.28 and 47.60 ± 2.16 µg/mL when compared with the reference drug
acarbose (IC
= 54.63 ± 1.95 µg/mL). Compounds 5g, 5o, 5s,and5x were screened
against the α‐amylase enzyme and were found to show excellent potential, with IC
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values ranging from 22.39 ± 1.40 to 32.07 ± 1.55 µg/mL, when compared with the
standard acarbose (IC
= 46.21 ± 1.49 µg/mL). The antioxidant activities of the
effective compounds (5o, 5g, 5s, 5x,and5q) were evaluated by TAS methods. A
molecular docking research study was conducted to identify the active site and explain
the functions of the active chemicals. To investigate the most likely binding mode of the
substances 5g, 5o, 5q, 5s,and5x, a molecular dynamics simulation was also carried out.
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