| dc.description.abstract | ABSTRACT
History
Received: 11/04/2023
Accepted: 22/09/2023
Hyperemesis gravidarum (HG) has severe, dramatic consequences, and the cause of this severe disease has not
yet been determined clearly. It is known that hormonal, metabolic, immunological, and inflammatory agents
may be effective in its etiology. Our study aimed to investigate the possible role of vitamin D, Lactate
Dehydrogenase (LDH), Procalcitonin (PCT), and C-reactive Protein (CRP) in the etiology of HG. In this
retrospective study, between June 1, 2021, and January 1, 2022, 110 pregnant women between 18 and 35 were
admitted to the Obstetrics and Gynecology Polyclinic of the Sivas Cumhuriyet University Faculty of Medicine.
Fifty-five patients diagnosed with HG were taken as a study group, and fifty-five healthy pregnant women not
diagnosed with HG were taken as a control group. Obstetric data and serum vitamin D, LDH, PCT, and CRP values
of pregnant women were detected retrospectively. When the groups with and without HG were compared,
although the CRP and LDH levels were high in the HG group, they were not statistically significant (p=0.084,
p=0.546). Vitamin D and PCT were significantly higher in the HG group than in the control group (p=0.001,
p=0.047). Our study found high vitamin D and PCT levels in pregnant women with HG. Further studies with more
participants are needed before these inflammatory markers can be used to diagnose HG. | tr |
