dc.contributor.author | YURTCU, Nazan | |
dc.contributor.author | Yarsilikal Guleroglu, Filiz | |
dc.contributor.author | Selvi, Esra | |
dc.contributor.author | uran Bakirci, Isil | |
dc.contributor.author | Bafaloı, Olgu | |
dc.contributor.author | Argun Atalmis, Hatice | |
dc.contributor.author | Çetin, Ali | |
dc.date.accessioned | 2024-03-07T11:38:48Z | |
dc.date.available | 2024-03-07T11:38:48Z | |
dc.date.issued | 2023/2 | tr |
dc.identifier.uri | https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1937-1155 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14925 | |
dc.description.abstract | Abstract
Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT).
Methods This observational study had groups of controls, including healthy pregnant women; women with only obesity, including pregnant women with BMI≥30 kg/m2; women with gestational DM (GDM) with obesity, including pregnant women with GDM and obesity; women with pregestational DM (PGDM) with obesity, including pregnant women with PGDM and obesity; and women with GHT with obesity, including pregnant women with GHT and obesity. We measured serum levels of selected biomarkers by ELISA.
ResultsObesity increased serum levels of all the biomarkers; GDM developed in obese women caused a more pronounced increase in the serum levels of BMP-4 and BMP-2, and GHT developed in obese women caused a more pronounced increase in the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated obesity, serum levels of MMP-9 and GP39 did not change meaningfully.
Conclusions Obesity and its comorbidities DM and GHT lead to meaningful changes in the studied serum biomarkers. Since obesity has a causal effect on developing numerous conditions, reliable clinical biomarkers are needed to improve the early prediction and diagnosis of high-risk conditions during pregnancy. | tr |
dc.language.iso | eng | tr |
dc.publisher | Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany | tr |
dc.relation.isversionof | DOI: 10.1055/a-1937-1155 | tr |
dc.rights | info:eu-repo/semantics/closedAccess | tr |
dc.subject | Pregnancy - obesity - diabetes mellitus - gestational hypertension - biomarker | tr |
dc.title | Clinical value of serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 levels in pregnant women with obesity and the related comorbidities diabetes mellitus and gestational hypertension | tr |
dc.type | article | tr |
dc.relation.journal | Zeitschrift für Geburtshilfe und Neonatologie | tr |
dc.contributor.department | Tıp Fakültesi | tr |
dc.contributor.authorID | 0000-0003-4725-043X | tr |
dc.identifier.volume | 227 | tr |
dc.identifier.issue | 01 | tr |
dc.identifier.endpage | 50 | tr |
dc.identifier.startpage | 42 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |