dc.contributor.author | Kıvrak, Mehmet Buğra | |
dc.contributor.author | Aydin, İbrahim | |
dc.date.accessioned | 2024-03-11T12:00:11Z | |
dc.date.available | 2024-03-11T12:00:11Z | |
dc.date.issued | 2023 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/15130 | |
dc.description.abstract | This study aimed to test the hypothesis that sulpiride can increase the concentration
of circulating gonadotropin that can promote puberty in pre-pubertal
ewe lambs.
Here, 12 1–3-
year-
old
Merino rams and 60 7–9-
month-
old
Merino sheep were included
in the study. The sheep were randomly divided into sulpiride (n = 30) and control
(n = 30) groups. The sulpiride group was subcutaneously injected with 0.6 mg/
kg sulpiride twice daily (morning and evening) for 9 days. During these 9 days, blood
samples were taken from the sheep before drug administration and at 4 h after every
drug administration. The number of ovulating animals in the sulpiride group was significantly
higher than that in the control group (90% vs. 32%). No oestrous signs were
observed in either group during ram release. Further, there were no differences in
the levels of mean follicle-stimulating
hormone in the two groups based on treatment
(p = .2), time (p = .3) or treatment-by-
time
interaction (p = .3). After sulpiride
administration, the luteinizing hormone (LH) levels of the sulpiride group rapidly increased
and remained stable for a long time, whereas physiological LH fluctuations in
the control group remained unchanged. Within-group
changes in terms of LH concentrations
were significant for both groups (p < .001), whereas LH pulse frequency was
significantly different between the sulpiride group (p = .03). Therefore, it is concluded
that sulpiride can be used as a non-steroidal
alternative to stimulate pre-pubertal
ewe
lambs and sheep during anoestrus. | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.title | Induction of ovulation using repeated doses of sulpiride, a dopamine antagonist, in ewe lambs | tr |
dc.type | article | tr |
dc.contributor.department | Sağlık Bilimleri Enstitüsü | tr |
dc.relation.publicationcategory | Rapor | tr |