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Leukotriene metabolism and proiflammatory cytokines in Crimean Congo hemorrhagic fever
(01.01.2023)Crimean–Congo hemorrhagic fever (CCHF) is an emerging acute viral infection disease, yet its pathophysiology remains largely uncharacterized. Lipid mediators are molecules that play numerous roles in the physiologic and ... -
Collaborative Clinical Research on Metabolomics
(23.10.2023)Metabolomics is the scientific study of chemical processes involving metabolites, substrates, intermediates, and namely all reagents and products of cell metabolism. Metabolomics and Clinical Approach will contribute to ... -
Sıçan Batın içi Endometriozis Modelinde VEGFR1-3 Kinaz İnhibitörü Frukuintinibin Etkisi: VEGF/VEGFR ve Hippo-Yap Moleküllerinin Rolü
(06.04.2023)Endometriozis, kadınların üreme saglıgı açısından önemli bir sorundur. Endometrioziste endometrial dokunun uterus dısında yayılması söz konusudur. Agrılı adet, pelvik agrı, agrılı cinsel iliski, infertilite ve diger ... -
Joint Research on Perinatology
(12.07.2023)Medical and surgical care have made considerable progress in the last two decades in the care of the mother, fetus, and neonate. Most of the improvement in outcomes has been related to advances in diagnostic and therapeutic ... -
Collaborative Clinical Research on Metabolomics
(23.10.2023)Metabolomikler nelerdir ve ilişkili klinik durumların güncel literatür eşliğinde araştırılması. Metabolomik analizlerin bu klinik durumlardaki hücresel yollakların araştırılması. -
Metabolomics in the Diagnosis of Pregnancy Complications
(2023/2)The pregnancy process is an intricate and unique period that requires control examinations to ensure the continuity of the well-being of the mother and the baby. The accompanying changes are also evident biologically, ... -
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
(Elsevier, 2023/3/5)The main aims of anticancer drug development studies is to reduce the toxicity of the developed com pound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, ... -
Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin
(Elsevier, 2023/9/15)Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The resin obtained from this plant is effective for different diseases. The chemical content of the ethanol ... -
Experimental and theoretical insights about the effect of some newly designed azomethine group‐contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
(Elsevier, 2023/8/5)We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ... -
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
(Bentham Science Publishers, 01.12.2023)Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body. Objectives: In this study, we aimed to investigate the relationship ... -
In Silico and In Vitro Studies of Novel Azomethines on DNA Repair Genes in Gastric Cell Lines
(MDPI, 28.09.2023)We herein report the determination of the cytotoxic activity and expression profiles of some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The studied novel compounds were ... -
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
(Elsevier, 05.02.2023)Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ... -
Antimicrobially effective protein-loaded metal chelated chitosan composite
(1 Ağustos )The immobilization of lysozyme onto a novel synthetic metal chelator composite based on chitosan/ PAA-PMA (chitosan/acrylamide-maleic acid) and its effect on antimicrobial activity were the aim of the current study. ... -
The Effect of Cycle Threshold Value on Predicting Prognosis in CrimeanCongo Hemorrhagic Fever Disease
(22.12.2023)Introduction: Crimean-Congo hemorrhagic fever (CCHF) disease is characterized by symptoms such as fever, headache, muscle aches, and bleeding. In severe cases, it can lead to death. Clinical and biochemical parameters, ... -
The experiences and thoughts of Turkish family physicians about COVID-19 pandemic: A qualitative study
(14.02.2023)Background: Efforts to contain the SARS-CoV-2 virus would fall short without strong primary health care. Objectives: In this study, we aimed to determine the experiences, views and suggestions of family physicians ... -
Medical Students' Views and Attitudes toward Vaccine Refusal during the COVID-19 Pandemic: A Multicenter Study
(20.04.2024)Background: The rapid development and production of COVID-19 vaccines have raised concerns about their safety and efficacy, which have contributed to vaccine hesitancy among some people. Objectives: This study aimed to ... -
The Turkish version of the problem areas in diabetes-parents of teens (P-PAID-T): Cross-cultural adaptation, reliability, and validity
(10.08.2023)Objective: To examine the Turkish validity and reliability of the Problem Areas in Diabetes- Parents of Teens (PPAID-T) scale and its psychometric properties for determining the parents’ diabetes-related distress. Methods: ... -
Psychometric Properties of the Turkish Validity and Reliability of the Parent Diabetes Distress Scale
(20.03.2023)Objective: The aim of this study was to evaluate the validity and reliability of the Turkish translation of the Parent Diabetes Distress Scale (PDDS). Methods: The PDDS is a 5-point Likert-type scale with 20 items. After ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
(2023)The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia
(2023)Morphine is a drug used in chronic pain such as diabetic neuropathy, but the development of tolerance to its antinoci ceptive efect is an important clinical problem. Aspirin is an analgesic and antiapoptotic drug used in ...