Browsing Cerrahi Tıp Bilimleri Bölümü by Author "0000-0003-4725-043X"
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6 IN VITRO ANTIPROLIFERATIVE ACTIVITIES OF ROYAL JELLY COLLECTED FROM SIVAS IN HUMAN OVARIAN CANCER (SK-OV-3) CELL LINE
Güzel, Mehmet Hakan; Daştan, Taner; Durna Daştan, Sevgi; Yurtcu, Nazan (2022/9/17)Royal jelly has positive effects on human health. It is a bee product and functional food. Royal jelly is secreted from the glands of hypopharyngeal and mandibular secretion tissue of young worker bees. It is a viscous ... -
Anticancer activity of Heat Shock Protein 70 (HSP70) Inhibitor, JG-98, against human cervical cancer HeLa and ovarian cancer SKOV-3 cells
YURTCU, Nazan; KARADEMİR, Dilay; Ergül Mustafa; Çetin, Ali; Tinelli, Andrea (Medicine Science International Medical Journal, 2023/3/1)Abstract Cervical and ovarian cancer are two aggressive neoplasms for women, still with high mortality and morbidity. Among the molecules and compounds that have anticancer activity, it was studied the JG-98, a heat shock ... -
Assessment of vaginal and endometrial microbiota by real‐time PCR in women with unexplained infertility
Sezer, Özlem; Caliskan, Canan; Çelik, Samettin; Kılıç, Süleyman Sırrı; Kuruoglu, Tuba; Unluguzel Ustun, Goksenin (2022/1)Abstract Aim Microbiota of the reproductive tract may be associated with unexplained infertility in women. We aimed to determine the derangements of vaginal and endometrial microbiota related to unexplained infertility ... -
Autoimmune Pathogenesis, Related Diseases and Laboratories
Yurtcu, Nazan; Demir, Kenan (01/08/2021)The immune system is a complex system that forms the defense mechanism against diseases in a living thing, recognizes and destroys pathogens and tumor cells, and protects the body from foreign and harmful substances. ... -
Clinical value of serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 levels in pregnant women with obesity and the related comorbidities diabetes mellitus and gestational hypertension
YARŞILIKAL, GÜLEROĞLU FİLİZ; SELVİ, ESRA; TURAN, BAKIRCI ISIL; Bafalı, Olgu; Argun Atalmış, Hatice; YASTI DAYAN, MERVE; BALKAN, ÖZMEN ALİYE; YURTCU, NAZAN; Seker Atas, Busra; Özdemir Anayurt, Esma; ÇETİN, ALİ (2023/2)Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT). Methods ... -
Clinical value of serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 levels in pregnant women with obesity and the related comorbidities diabetes mellitus and gestational hypertension
YURTCU, Nazan; Yarsilikal Guleroglu, Filiz; Selvi, Esra; uran Bakirci, Isil; Bafaloı, Olgu; Argun Atalmis, Hatice; Çetin, Ali (Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany, 2023/2)Abstract Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension ... -
Current Topics in Perinatology and Neonatology
Yurtcu, Nazan; Çetin, Ali (NOVA SCIENCE PUBLISHERS, INC, April 10, )Medical and surgical care have made considerable progress in the last two decades in the care of the mother, fetus, and neonate. Most of the improvement in outcomes has been related to advances in diagnostic and therapeutic ... -
Derangements of vaginal and cervical canal microbiota determined with real-time PCR in women with recurrent miscarriages
Caliskan, Canan; Yurtcu, Nazan; Çelik, Samettin; Sezer, Özlem; Kılıç, Süleyman Sırrı; Çetin, Ali (2022/8/18)Balanced vaginal microbiota and, as a continuum, cervical canal microbiota help prevent reproductive disorders, including recurrent miscarriage (RM). In a significant proportion of couples with RM, routine diagnostic workup ... -
Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death/Otofaji ile iliskili hucrelerde subkutan endometriozis fare modelinde metformin ve genireliksin etkisi.
YURTCU, Nazan; Sönmez Ünal, Gamze; Albak, Yasemin; Yıldız, Çağlar; Çetin, Meral; DURNA DAŞTAN, SEVGİ (Galenos Yayinevi Tic. Ltd., Eylül/2023)Objective This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model. Materials and Methods Five groups were formed with eight ... -
Epigenetics: Beyond the Genetics and Medicine
Yurtcu, Nazan; Durna Daştan, Sevgi (27.10.2022)The Publisher has taken reasonable care in the preparation of this book, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for ... -
Histopathological Evaluation of Endometrium Cancers
Göç, Rümeysa; Yurtcu, Nazan (16/09/2021)Introduction: Endometrial cancer is the fourth most common cancer of the genital tract, while it is the fourth most common malignancy in women. The aim of this study is to share the surgical treatment and results of cases ... -
HPV VE SERVİKAL PREKANSERÖZ LEZYONLAR, SAĞLIK & BİLİM 2022 GÜNCEL TIP-II
Yurtcu, Nazan (2022)Servikal prekanserler, yavaş yavaş invaziv kansere ilerleyen intraepitelyal preinvaziv lezyonlardır. Bu gelişme yaklaşık 10-15 yıl içerisinde oluşmaktadır. Kadınların yaşamını ve sağlığını tehdit eden malign tümörlerden ... -
Investigation Cytotoxic effect of HSP70 Inhibitör JG-98 0n K562 Chronic Myeloid Leukemia Cells
Dalkılıç Fatmanur; Yurtcu, Nazan; ERGÜL MUSTAFA (2022/09/18)Abstract Hsp70 weighs approximately 70 kDa (66-78 kDa) and is the best-preserved and best characterized Hsp family among living organisms [1]. Hsp70 is a molecular chaperone with physiological roles such as folding of ... -
Polikistik Over Sendromlu Hastalarda Obezite ve Lipid Profilinin Karotis İntima Kalınlığı ile İlişkisi
Yurtcu, Nazan; KARADEMİR, Dilay; SERİN Sercan (2022/11)Amaç Polikistik over sendromu (PKOS), Üreme çağındaki kadınlarda önemli bir reprodüktif bozukluk olup, metabolik rahatsızlıklar ve kardiyovasküler hastalıklara da yol açabilmektedir. Bu çalışma, PCOS hastalarında Karotis ... -
Prediction of gestational diabetes mellitus and perinatal outcomes by plasma zonulin levels
Oral, Serkan; Çelik, Sebahattin; Akpak, Yasam Kemal; Golbasi, Hakan; Bayraktar, Burak; Unver, Gokhan; Sahin, Sami; Yurtcu, Nazan; Caliskan, Canan (2022/8/22)Abstract Purpose: Zonulin has been shown to be associated with many metabolic disorders, including type 2 diabetes mellitus, metabolic syndrome, and obesity. In this study, we aimed to evaluate the association between ... -
Predictive and Diagnostic Value of Serum Adipokines in Pregnant Women with Intrahepatic Cholestasis
Yurtcu, Nazan; Caliskan, Canan; Güney, Huri; Çelik, Samettin; Hatırnaz, Şafak; Tinelli, Andrea (2022/2/16)The objective of this study was to assess the value of serum leptin, adiponectin, apelin, and ghrelin as biomarkers for the prediction and diagnosis of intra-hepatic cholestasis (ICP). This prospective study included ... -
Predictive and diagnostic value of serum sVEGFR-1 level in women with preeclampsia: A prospective controlled study
Salk, Sultan; YURTCU, Nazan; Çetin, Ali (2022/12)Abstract Objective: Pre-eclampsia (PE), a pregnancy-specific syndrome consisting of hypertension and proteinuria occurring de novo after the 20th week of gestation, remains the leading cause of maternal and fetal morbidity ... -
Predictive and Prognostic Value of Plasma Zonulin for Gestational Diabetes Mellitus in Women at 24–28 Weeks of Gestation
Yılmaz Zehra; Oral, Serkan; Yurtcu, Nazan; Akpak, Yasam Kemal; Çelik, Sebahattin; Caliskan, Canan (2022/12)Objective We aimed to examine the predictive and prognostic value of plasma zonulin for gestational diabetes mellitus (GDM) in women at 24–28 weeks of gestation. Methods This retrospective study was carried out with ... -
Predictive value of pregnancy of follicular fluid fetuin-A and-B levels in infertile women after intra-cytoplasmic sperm injection
Yurtcu, Nazan (2021/12)AimWe aimed to investigate the value of follicular fluid Fetuins-A and -B to predict successful IVF and pregnancy outcomes in infertile women with poor, normal, and high ovarian reserve. MethodsThe follicular fluid of 96 ... -
Pregnancy and Cytokines, Cytokines and Diseases
Yurtcu, Nazan; Durna Daştan, Sevgi (2022)ABSTRACT Pregnancy is a physiological state designated as the regional immune tolerance of the mother organism against paternal sourced antigens found in embryonic cells. While the paternal heritage makes half of the ...