Browsing Klinik Öncesi Bilimleri Bölümü by Author "1a5f292a-8bbc-4605-a5fa-a95de625d2a4"
Now showing items 1-7 of 7
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Carvacrol Mitigates Bleomycin Induced Experimental Pulmonary Fibrosis
Nergiz Hacer TURGUT; Hüseyin GÜNGÖR; Mehmet EKİCİ; Mehmet Önder KARAYİĞİT; Haki KARA (23/08/2023)Idiopathic pulmonary fibrosis (IPF) is a serious progressive pulmonary disease of unknown etiology and high mortality. Carvacrol is a natural phenolic monoterpene with various pharmacological effects, especially antioxidant ... -
Kaempferol and Isorhamnetin alleviate Lipopolysaccharide-Induced Anxiety and Depression-Like Behavioral in Balb/C Mice
Mehmet EKİCİ; Hüseyin GÜNGÖR; Derya Güliz MERT (09/07/2023)The etiology of anxiety and depression is linked to inflammation and oxidative stress. Isorhamnetin and Kaempferol are strong antioxidants with anti-inflammatory neuroprotective properties. This study, it was aimed to ... -
Lipid-lowering, antiinflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
Hüseyin GÜNGÖR; Mehmet EKİCİ; Mehmet Burak ATEŞ (05/2023)Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen (APAP) induced hepatotoxicity is still ... -
Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep
Hüseyin GÜNGÖR; Orhan ÇORUM; Duygu Durna ÇORUM; Alper Serhat KUMRU; Gökhan YILMAZ; Devran COŞKUN; Alparslan COŞKUN; Kamil ÜNEY (13/09/2023)The aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was ... -
Phenolic profile and investigation of biological activities of Allium scorodoprasum L. subsp. rotundum
Tuğba DEMİR; Özlem AKPINAR; Haki KARA; Hüseyin GÜNGÖR (06/01/2022)In this study, phenolic profile of Allium scorodoprasum L. subsp. rotundum and its bioactivity in multiway approach including antioxidant, antimicrobial, antidiabetic, cytotoxic and antiinflamatory activities were investigated. ... -
Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity in rats
Yasemin KORKMAZ; Hüseyin GÜNGÖR; Ahmet DEMİRBAŞ; Burak DİK (26/07/2023)Cadmium is a major environmental pollutant and a highly toxic metal. It was aimed to determine the effects of pomegranate peel extract (PPE), N-acetylcysteine (NAC) alone and along with Ornipural on cadmium-induced ... -
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats
Hüseyin GÜNGÖR; Mehmet EKİCİ; Özhan KARATAŞ; Burak DİK (05/05/2023)Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on ...