Browsing Klinik Öncesi Bilimleri Bölümü by Author "43a1ca38-d540-47eb-9162-964314720f05"
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Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line
Taştemur, Şeyma; Hacısüleyman, Levent; Karataş, Özhan; Yulak Fatih; Ataseven Hilmi (28.04.2023)Colorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative of hydroxycinnamic acid, is a promising phytochemical exhibiting numerous pharmacological activities ... -
Cardioprotective Effect of Empagliflozin in Rats with IsoproterenolInduced Myocardial Infarction: Evaluation of Lipid Profile, Oxidative Stress, Inflammation, DNA Damage, and Apoptosis
Ekici, Mehmet; Güngör, Hüseyin; Karayiğit, Mehmet Önder; Turgut, Nergiz Hacer; Koçkaya, Mustafa; Karataş, Özhan; Üner, Aykut Göktürk (PLEIADES PUBLISHING INC, 2022-11-13)—The antidiabetic drug empagliflozin is reported to have many cardioprotective effects. However, no studies have investigated the protective effects of empagliflozin (EMPA) in isoprenaline (ISO)-induced cardiac oxidative ... -
Effects of Lavender (Lavandula Angustifolia) Essential Oil on Fattening Performance, Meat Quality, Serum Antioxidant Enzymes, Gut Microbiota and Intestinal Histomorphology in Japanese Quails
Özbilgin, Abdullah; Moğulkoç, Mahmut Niyazi; Kara, Kanber; Urçar, Sevda; Karataş, Özhan; Ülger Özbek, Dilara (31.07.2023)This study examined the effects of lavender essential oil on performance, meat quality, microbial load, fatty acid profile and gut microbiota in quails. In the study, 200 quails (Coturnix coturnix Japonica) were divided ... -
FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease
Çetindağ Çiltaş, Arzuhan; Karabulut Sebahattin; Şahin Bilal; Filiz, Ahmet Kemal; Yulak Fatih; Özkaraca Mustafa; Karataş, Özhan; Çetin, Ali (22.07.2023)Alzheimer’s disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) ... -
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
Joha, Ziad; Öztürk Ayşegül; Yulak Fatih; Karataş, Özhan; Ataseven Hilmi (16.08.2023)Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ... -
Mitochondrial Homeostasis and Mast Cells in Experimental Hepatic Ischemia-Reperfusion Injury of Rats
Koç, Süleyman; Doğan, Halef Okan; Karataş, Özhan; Erdoğan, Mehmet Mustafa; Polat, Vural (TURKISH JOURNAL OF GASTROENTEROLOGY, 2022-10-22)Background: Ischemia-reperfusion injury is a histopathological event and is an important cause of morbidity and mortality after hepatobiliary surgery. We aimed to investigate the protective effect of uridine on hepatic ... -
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats
Güngör, Hüseyin; Ekici, Mehmet; Karataş, Özhan; Dik, Burak (20.02.2023)Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on ... -
Şap Hastalığı
Karataş, Özhan (Foot and Mouth Disease, 2022)Şap hastalığı çiftlik hayvanlarının bulaşıcı, maddi kayıplara yol açan ve 500 yıla yakın geçmişe sahip, viral bir hastalığıdır. Hastalığa ait 5 tip ülkemizde görülmüş ve canlı – cansız pek çok vektörle bulaşım olabileceği ... -
The effects of sorafenib in healthy and cisplatin-treated rats
Demirtaş, Levent; Gürbüzel, Mehmet; Tahirler, Hilal; Akbaş, Emin Murat; Karataş, Özhan; Arslan, Yusuf Kemal (07.10.2023)Background. Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer. Objectives. The literature on this agent is scarce. This study aimed ... -
The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats
Demirtaş, Levent; Gürbüzel, Mehmet; Akbaş, Emin Murat; Tahirler, Hilal; Karataş, Özhan; Arslan, Yusuf Kemal (04.01.2023)Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine ...