Browsing Temel Tıp Bilimleri Bölümü Makale Koleksiyonu by Author "2029e519-db45-4c0c-80d2-46fc2f0a991c"
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A novel therapeutic approach to NASH: Both polyethylene glycol 3350 and lactulose reduce hepatic inflammation in C57BL/6J mice.
Pinar Gokcen; Oguzhan Ozturk; Gupse Adali; Ilkay Tosun; Halef Okan Dogan; Haki Kara; Yucel Yalman; Hamdi Doganay; Kamil Ozdil (2021)Background. The gut-liver axis is one of the most emphasized topics in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Intestinal microbiota dysbiosis has been shown to be a predictor of disease severity and ... -
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
Halef Okan Dogan (2023)Objectives: Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ... -
The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19
Halef Okan Dogan; Serkan Bolat; Seyit A Büyüktuna; Rağıp Sarıismailoğlu; Nazım Çetinkaya; Kübra Doğan; Mürşit Hasbek; Halil Caylak (2021)Objectives It is vital to determine the intensive care unit (ICU) requirement at an early stage to reduce the mortality rate in COVID-19 patients. The aim of the study was to find reliable predictive markers to determine ... -
Understanding the pathophysiological changes via untargeted metabolomics in COVID‐19 patients
Halef Okan Dogan; onur şenol; Serkan Bolat; Şeyma N Yıldız; Seyit A Büyüktuna; Rağıp Sarıismailoğlu; Kübra Doğan; Mürşit Hasbek; Süleyman N Hekim (Wiley, 2021 Nisan)Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular responses of COVID-19. In this study, we aimed ...