Browsing Temel Tıp Bilimleri Bölümü Makale Koleksiyonu by Author "0000-0001-8738-0760"
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A novel therapeutic approach to NASH: Both polyethylene glycol 3350 and lactulose reduce hepatic inflammation in C57BL/6J mice.
Pinar Gokcen; Oguzhan Ozturk; Gupse Adali; Ilkay Tosun; Halef Okan Dogan; Haki Kara; Yucel Yalman; Hamdi Doganay; Kamil Ozdil (2021)Background. The gut-liver axis is one of the most emphasized topics in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Intestinal microbiota dysbiosis has been shown to be a predictor of disease severity and ... -
Assessment of semaphorin 3A and semaphorin 7A levels in primary Sjogren's syndrome
Urhan, Emre; Urhan, Ayse Camci; Dogan, Halef Okan; Sahin, Ali (Springer, 2022/8/28)Sjogren's syndrome (SS) is a chronic autoimmune connective tissue disease. Varying rates of system involvements may be seen in the course of the disease. Semaphorins has multifunctions in several physiological and pathological ... -
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
Halef Okan Dogan (2023)Objectives: Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ... -
Mitochondrial Homeostasis and Mast Cells in Experimental Hepatic Ischemia-Reperfusion Injury of Rats.
Background: Ischemia-reperfusion injury is a histopathological event and is an important cause of morbidity and mortality after hepatobiliary surgery. We aimed to investigate the protective effect of uridine on hepatic ... -
The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19
Halef Okan Dogan; Serkan Bolat; Seyit A Büyüktuna; Rağıp Sarıismailoğlu; Nazım Çetinkaya; Kübra Doğan; Mürşit Hasbek; Halil Caylak (2021)Objectives It is vital to determine the intensive care unit (ICU) requirement at an early stage to reduce the mortality rate in COVID-19 patients. The aim of the study was to find reliable predictive markers to determine ... -
Understanding the pathophysiological changes via untargeted metabolomics in COVID‐19 patients
Halef Okan Dogan; onur şenol; Serkan Bolat; Şeyma N Yıldız; Seyit A Büyüktuna; Rağıp Sarıismailoğlu; Kübra Doğan; Mürşit Hasbek; Süleyman N Hekim (Wiley, 2021 Nisan)Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular responses of COVID-19. In this study, we aimed ... -
Validation of Friedewald, Martin-Hopkins and Sampson low-density lipoprotein cholesterol equations
Gözde Ertürk Zararsız; Serkan Bolat; Ahu Cephe; Necla Kochan; Serra İlayda Yerlitaş; Halef Okan Doğan; Gökmen Zararsız (2022/5/13)Background: Low-density lipoprotein cholesterol (LDL-C) is an important biomarker for determining cardiovascular risk and regulating lipid lowering therapy. Therefore, the accurate estimation of LDL-C concentration is ...