Browsing Makale Koleksiyonu by Author "Parlak, Ahmet"
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Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
Karadas, Baris; Kaya, Tijen; Gulturk, Sefa; Parlak, Ahmet; Gursoy, Sinan; Cetin, Ali; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2007)Nimesulide, celecoxib, and DFU (5, 5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone) are nonsteroidal antiinflammatory drugs (NSAIDs) with selective cyclo-oxygenase (COX)-2 blocking properties and ... -
Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
Gursoy, Nevcihan; Sarac, Bulent; Durmus, Nedim; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen; Bagcivan, Ihsan (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ... -
Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy
Karadas, Baris; Kaya, Tijen; Cetin, Meral; Parlak, Ahmet; Durmus, Nedim; Bagcivan, Ihsan; Gulturk, Sefa (ELSEVIER SCIENCE INC, 2007)Alterations in vascular responses to beta-adrenoceptor agonists in normotensive pregnancy and pre-eclampsia are not fully understood. Thus, we studied changes in vasodilator responses to beta(2)-adrenoceptor agonist ... -
Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions
Gursoy, Nevcihan; Durmus, Nedim; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have ... -
Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea
Cevit, Omer; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Durmus, Nedim; Kava, Tiien (ELSEVIER SCIENCE BV, 2007)Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations ... -
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
Toker, Mustafa; Bagcivan, Ihsan; Topalkara, Aysen; Karadas, Baris; Durmus, Nedim; Parlak, Ahmet; Kaya, Tijen (MARY ANN LIEBERT, INC, 2008)Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant ... -
Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery
Disli, Olcay Murat; Ozdemir, Ercan; Berkan, Ocal; Bagcivan, Ihsan; Durmus, Nedim; Parlak, Ahmet (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2009)Radial artery (RA) vasospasm remains a potential cause of early graft failure after coronary artery bypass graft surgery, despite pretreatment with alpha-adrenergic or calcium channel blockers. Our aim was to investigate ... -
Role of new agents affecting NO/cGMP pathway on ovalbumin-sensitized guinea pig trachea
Parlak, Ahmet; Yildirim, Sahin; Bagcivan, Ihsan; Durmus, Nedim (INFORMA HEALTHCARE, 2012)Asthma is a chronic inflammatory disease in which cell components play important roles. We aimed to evaluate the effects of NO/cGMP cleavage at trachea preparations isolated from ovalbumin-sensitized guinea pigs in vitro. ...