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The effects of endocannabinoid receptor agonist anandamide and antagonist rimonabant on opioid analgesia and tolerance in rats
(GENERAL PHYSIOL AND BIOPHYSICS, 2015)
The role of the cannabinoid (CB) system in the tolerance to analgesic effect of opioid remains obscure. The aim of the present study was to evaluate the effects of the endocannabinoid nonselective receptor agonist anandamide ...
Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats
(TAYLOR & FRANCIS LTD, 2011)
Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate ...
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft
(NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2007)
The radial artery (RA) is used as a spastic coronary bypass graft. This study was designed to investigate the mechanism of vasorelaxant effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a nitric oxide ...
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits
(BLACKWELL PUBLISHING, 2006)
Introduction. The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism ...
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
(MARY ANN LIEBERT, INC, 2008)
Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant ...
Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ...
The effects of serotonin/norepinephrine reuptake inhibitors and serotonin receptor agonist on morphine analgesia and tolerance in rats
(SPRINGER TOKYO, 2012)
Several studies have demonstrated that serotonergic and noradrenergic systems have important roles in morphine analgesia and tolerance. However, the exact mechanism underlying the development of morphine tolerance is not ...
Effects of intravenous anesthetics on the human radial artery used as a coronary artery bypass graft
(W B SAUNDERS CO-ELSEVIER INC, 2007)
Objective: Intravenous anesthetics are often used for anesthesia, sedation, and analgesia in the intraoperative and postoperative periods of coronary artery bypass graft (CABG) surgery. This study was designed to investigate ...
Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea
(ELSEVIER SCIENCE BV, 2007)
Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations ...
Investigation of the relaxant effects of pinacidil and Cromakalim on the sheep sphincter of Oddi
(KARGER, 2006)
Background/Aims: ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. This study was designed to investigate the effects of pinacidil and cromakalim, KATP-sensitive ...