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Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)
Background: A large variety of familiar and non-familiar lung carcinomas (LC) are caused by long term exposure to chemical carcinogens that are present in tobacco smoke. We aimed to investigate the prevalence of 5 thrombophilic ...
Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)
Background: Various oncogenes related to cancer have been extensively studied and several polymorphisms have been found to be associated with breast cancer. The current report outlines analysis of germ-line polymorphisms ...
Clinical and molecular analysis of common MEFV gene mutations in familial Mediterranean fever in Sivas population
(SPRINGER, 2009)
Familial Mediterranean fever (FMF) is the most frequent hereditary inflammatory disease characterized by self-limited recurrent attacks of fever and serositis. The aim of the current study is to determine the frequency of ...
The Presence of PAI-1 4G/5G and ACE DD Genotypes Increases the Risk of Early-Stage AVF Thrombosis in Hemodialysis Patients
(TAYLOR & FRANCIS LTD, 2011)
Background: In this study, we investigated the relationship between early arteriovenous fistula (AVF) thrombosis with angiotensin-converting enzyme (ACE) gene and thrombophilic factor gene polymorphisms. Methods: Thirty-five ...
Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension
(K FAISAL SPEC HOSP RES CENTRE, 2014)
BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic ...
Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus
(KOWSAR PUBL, 2013)
Background: To treat viral infection of chronic hepatitis C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in ...
Methylenetetrahydrofolate Reductase Gene Germ-Line C677T and A1298C SNPs are Associated with Colorectal Cancer Risk in the Turkish Population
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)
Colorectal cancer (CRC) is the third most common cause of death due to cancer in the worldwide and the incidence is also increasing in Turkey. Our present aim was to investigate any association between germ-line ...
Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study
(SAGE PUBLICATIONS INC, 2011)
Materials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. ...
Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C > T Gene Polymorphism in Differentiated Thyroid Cancers
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)
Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine ...
Prevelance of Common YMDD Motif Mutations in Long Term Treated Chronic HBV Infections in a Turkish Population
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)
In the current study we aimed to show the common YMDD motif mutations in viral polymerase gene in chronic hepatitis B patients during lamivudine and adefovir therapy. Forty-one serum samples obtained from chronic hepatitis ...