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Now showing items 31-40 of 43
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine
(CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2011)
Although the phenomenon of opioid tolerance has been widely investigated, neither opioid nor nonopioid mechanisms are completely understood. The aim of the present study was to investigate the role of the nitric oxide ...
Investigation of Relaxant Effects of New Agents Affecting Nitric Oxide/Cyclic Guanosine Monophosphate Pathway on Sheep Oddi Sphincter
(LIPPINCOTT WILLIAMS & WILKINS, 2010)
Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting ...
Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
(ELSEVIER SCIENCE BV, 2007)
Nimesulide, celecoxib, and DFU (5, 5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone) are nonsteroidal antiinflammatory drugs (NSAIDs) with selective cyclo-oxygenase (COX)-2 blocking properties and ...
Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists
(SPRINGER JAPAN KK, 2015)
Cannabinoid CB1 and CB2 receptor antagonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The aim of this study was to investigate the ...
Investigation of the Relaxant Effect Mechanism of Ketamine on Normal and Ovalbumin-Induced Trachea in Guinea Pigs
(ORTADOGU AD PRES & PUBL CO, 2011)
Objective: The aim of this study was to investigate of effects and the possible mechanisms of effects of ketamine on the isolated trachea preparations from control and ovalbumin sensitized guinea pigs. Material and Methods: ...
Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft
(MOSBY-ELSEVIER, 2015)
Objective: Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and that are commonly prescribed after cardiac ...
Investigation of relaxant effects of propofol on sheep sphincter of Oddi
(KARGER, 2007)
Background/Aims: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangio-pancreatography ( ERCP) and endoscopic sphincter of Oddi ( SO) manometry. This study was designed to investigate ...
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model
(ELSEVIER SCIENCE BV, 2008)
The pathophysiology of pre-eclampsia is still unknown thus effective primary prevention is not possible at the stage. The present study was conducted to research the smooth muscle responses in the pre-eclampsia model with ...
Ineffective Doses of Dexmedetomidine Potentiates the Antinociception Induced by Morphine and Fentanyl in Acute Pain Model
(KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2013)
The aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats. Seventy albino Wistar rats ...
Alterations in spontaneous contractions of rat proximal and distal colon after peritonitis
(W B SAUNDERS CO-ELSEVIER INC, 2007)
Background/ Purpose: The aim of this study was to investigate the effect of peritonitis on spontaneous contractions of distal and proximal colon smooth muscle isolated from rats. Methods: Peritonitis was induced by cecal ...