Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Access Type "info:eu-repo/semantics/openAccess"
Now showing items 21-40 of 58
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Determination of phenolic compounds in human saliva after oral administration of red wine by high performance liquid chromatography
(Elsevier, 05.02.2022)Search ScienceDirect Outline Highlights Abstract Keywords 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusions Declaration of Competing Interest Acknowledgments Appendix A. Supplementary ... -
Determination of Sulfadiazine in Natural Waters by Pine Needle Biochar - Derivatized Magnetic Nanocomposite Based Solid-Phase Extraction (SPE) with High-Performance Liquid Chromatography (HPLC)
(Taylor&Francis, 26/03/2022)A magnetic solid-phase extraction (MSPE) method was developed for the facile and sensitive determination of sulfadiazine prior to high-performance liquid chromatography (HPLC) analysis. The magnetic sorbent was prepared ... -
Determination of Sulfadiazine in Natural Waters by Pine Needle Biochar – Derivatized Magnetic Nanocomposite Based Solid-Phase Extraction (SPE) with High-Performance Liquid Chromatography (HPLC)
(06.04.2022)A magnetic solid-phase extraction (MSPE) method was developed forthe facile and sensitive determination of sulfadiazine prior to high-performance liquid chromatography (HPLC) analysis. The magneticsorbent was prepared by ... -
Determination of sunset yellow, allura red, and fast green using a novel magnetic nanoadsorbent modified with Elaeagnus angustifolia based on magnetic solid-phase extraction by HPLC
(UNIV SAO PAULO, CONJUNTO QUIMICAS, 2022)Sunset yellow (SY), allura red (AR) and fast green (FG) are frequently used in commercial food products, although they are considered to be hazardous to public health due to their toxic efficacy and high exposure risk ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex /double-stranded DNA biosensor
(Elsevier, 2022)In the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and doublestranded DNA. The ... -
Emerging Trends in Pharmacotoxicological and Forensic Sample Treatment Procedures
(MDPI, 22 Februar)One of the most discussed topics concerns the sample preparation before the analysis and, therefore, all the operations necessary to eliminate the interferents, clean up the specimens, and extract the analytes of interest, ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(Royal Society of Chemistry, 21.09.2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Güncel Uygulanan Kanser Tedavi Yöntemleri
(Bilgin Kültür Sanat Yayınları, 25.12.2022)Modern tıp her ne kadar ilerlemiş olsa da kanser için hastalık görülmeden önce ortaya çıkarılması ve erken safhada önlenmesi hala çok önemlidir. Kansere karşı koruyucu olarak; en büyük nedenlerinden biri olan sigara ve ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
(19.06.2023)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Interaction of water soluble cationic gallium (III) phthalocyanines with different G-quadruplex DNAs
(Elsevier, 1 November)Small molecule-G-quadruplex DNA interaction has been gained considerable interest due to existence of G-quadruplex structures in telomeres and promotor regions of proto-oncogenes. In the present study, the interaction of ... -
Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods
(2021/9/15)DNA is an important target for the development of chemotherapeutic drug design due to increased and uncontrolled cell proliferation of cancer cells. In the present study, the affinity of water-soluble gallium(III) ... -
Investigation of Interaction of Bismarck Brown Y-Palladium Complex with AS1411 G-quadruplex Aptamer
(29.12.2022)Increased metabolic activity and metastasis are the main and most known characteristics of cancer cells. Increased activity of the cells results in an increase in the transcription, translation, and replication rate of ... -
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
(2022)Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their ... -
Magnetic solid-phase extraction coupled to high-performance liquid chromatography (HPLC)-diode array detection method has been developed for the sensitive analysis of Anastrozole (ANA) and Letrozole (LET) in human urine samples. Characterization studies of the newly synthesized material (Fe3O4@TEPA) were carried out by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, Raman spectroscopy, and scanning electron microscope techniques. The method has provided linearity for both the analytes (r2 > 0.9900) in the range of 4.00–160.00 ng mL−1. The limit of detections for ANA and LET was found to be 1.14 and 1.26 ng mL−1, respectively. The limit of quantification for ANA and LET was obtained 3.78 and 3.86 ng mL−1, respectively. The new method was simple, convenient, fast, and suitable for the direct analysis of ANA and LET in urine samples. Finally, the developed method was applied to the spiked human urine samples to test accuracy and repeatability. Recovery values for each of the molecules were calculated in the range of 93.4–108.0% (n = 3) at two concentration levels, while % RSDs were lower than 6.2%. Graphical abstract
(Elsevier, 15.04.2022)A new Polyacrylamide (PAA)-Vermiculite (V) composite was synthesized and characterized with the help of FTIR, SEM, and PZC analyses. The effects of ion concentration, pH and ionic strength parameters to adsorption process ... -
New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
(23.01.2023)Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized with different spectroscopic techniques such as 1 HNMR, 13 CNMR,andHRMS.The synthesized analogs were examined against α‐glucosidase ... -
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi- ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity of the ... -
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
(MDPI, 15.02.2022)In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
(Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ... -
Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
(Taylor & Francis, 2022/01/26)A new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ... -
Removal of sulfadiazine from aqueous solution by magnetic biochar prepared with pomegranate peel
(Taylor&Francis, 17/05/2022)Magnetic biochar (Fe3O4-BCPP) was prepared by using iron oxide nanoparticles, and biochar which is obtained from pomegranate peel. The Fe3O4-BCPP were characterized by Brunauer-Emmett-Teller analysis, X-ray diffraction ...