Browsing Uygulama ve Araştırma Merkezleri by Issue Date
Now showing items 1-20 of 36
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SIRT1, MMP-9 and TIMP-1 levels in children with specific learning disorder
(Elsevier, 01.0.8.202)bstract Background Specific Learning Disorder (SLD) is a common developmental and neurobiological disorder of childhood characterized by impairment of functionality in one or more areas such as reading, writing, mathematics, ... -
Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection
(Proceedings of the National Academy of Sciences of the United States of America, 05.09.2023)Crimean-Congo hemorrhagic fever (CCHF) caused by CCHF virus (CCHFV) is one of the epidemic-prone diseases prioritized by the World Health Organisation as public health emergency with an urgent need for accelerated research. ... -
SINGLE-CELL MASS CYTOMETRY AND TRANSCRIPTOME PROFILING
(09.12.2023)Single-cell cytometry, a research tool, has been used for almost half a century. Flow cytometry has long been the primary method for cytometric analysis, and data processing/analysis operations have been heavily influenced ... -
MULTIOMICS: HUMAN DISEASES AND MACHINE LEARNING
(09.12.2023)Integrating different types of omics data with each other can help learn clinical-pathogenic changes that may be the cause of the disease, and these analyzes can be tested and confirmed by molecular studies in the next ... -
IN SILICO ACTIVITY PREDICTION: ADME-TOX ASSESSMENT AND MOLECULAR DYNAMICS
(18.12.2023)The way to create new drugs is to map out the hallmarks of a disease by finding small molecules that can modulate the function of known target molecules. Furthermore, there is a need to identify and obtain small molecules ... -
COMPARISON OF DNA SEQUENCING TECHNOLOGIES IN CLINICAL SAMPLES: NEXT-GENERATION AND THIRD-GENERATION SEQUENCING
(18.12.2023)Determining the exact base, or nucleotide sequence, of a DNA molecule is a common laboratory procedure called "DNA sequencing." There is always a need to create new, updated series analyses. Major sequencing achievements, ... -
Sivas Kent Araştırmaları Kaynakçası : Millî Mücadele ve Sivas Kongresi'nin 100. Yılı Anısına
(Sivas Cumhuriyet Üniversitesi, 2020)Osmanlı döneminde şehirlerin güzelliklerini anlatan "Şehrengiz" tarzı eserlerin yazıldığı bilinmektedir. şehrengiz geleneği, özellikle XVI. ve XVIII. yüzyıllar arası dönemde yoğun olarak sürdürülmüştür. XIX. ve ... -
CAENORHABDITIS ELEGANS MODEL ORGANİZMASINDA TRANSKRİPTOM VE METABOLOM ANALİZLERİ
(Serüven Yayınevi, 2022)GİRİŞ Metabonomi veya metabolomik, spektrometri ve genomik araştırma- ları sonrası bu teknolojiler ile geliştirilen yeni bir “omik” disiplini olup, genellikle, canlı sistemlerdeki tüm metabolitlerin ve eksojen uyaranlara, ... -
MOLEKÜLER TÜR TANIMLAMASINDA BIR ARAÇ OLARAK DNA BARKODLAMA
(2022)GİRİŞ Türlerin taksonomik tanımlamasında DNA kullanma kavramı ilk olarak Hebert ve Gregory tarafından önerilmiştir (P. D. Hebert ve ark., 2003). DNA barkodlama kavramı, türleri birbirinden ayırmak için kullanılabilen ... -
OMURGASIZ ANTİMİKROBİYAL PEPTİDLERİ: POTANSİYEL TERAPÖTİK UYGULAMALAR
(İKSAD YAYINEVİ, 2022)GİRİŞ Konak savunma peptidleri veya antimikrobiyal peptidler (AMP'ler), doğuştan gelen bağışıklık sisteminin en önemli anahtar bileşenlerinden biridir (Zasloff, 2002; Hancock ve ark., 2012). Enfeksiyöz ajanlara karşı ilk ... -
EPİGENETİK VE KANSER
(2023)Epigenetik terimi ilk kez 1942'de Conrad Waddington'un geno-tip ile fenotip arasındaki bağlantıyı yorumlamaya çalışmasıyla önerilmiş ve "genler ve ürünleri arasındaki nedensel etkileşimleri inceleyen ve fenotipi ortaya ... -
BİYOAKTİF PEPTİDLERDE IN SILICO ANALİZLER
(2023)Biyolojik olarak aktif peptidler (biyoaktif peptidler), peptid bağlarıyla birleştirilmiş 2-20 amino asit rezidüsü içeren ve pozitif biyolojik etkiler sergileyen protein fragmanlarıdır. Gıda proteinleri, biyoaktif peptidler ... -
The investigation of host genetic variants of toll-like receptor 7 and 8 in COVID-19.
(2023)Toll-like receptors (TLRs) recognize infectious agents and play an important role in the innate immune system. Studies have suggested that TLR single nucleotide polymorphisms (SNPs) are associated with poor antiviral ... -
DNA Barcoding of Commercial Cockroaches in Turkey
(2023)Accurate species identification has become a precondition for accomplished biodiversity administration and further genetic research. Species acquaintance technics require molecular tools such as DNA barcoding as well as ... -
RNAi Terapötikleri: Viral Hastalıklar ve Kanser
(2023)RNA interferens (RNAi), bir gen dizisini tamamlayıcı olan ve hedeflenen dizinin spesifik susturulmasına aracılık eden, tipik olarak 19-23 nükleotidden oluşan kısa RNA dizilerinin temel prensibine dayanır (Kelleher ve ark., ... -
Levels of oxidative stress and apoptosis-related biomarkers in endometriosis
(Cukurova Üniverstesi, 2023)Abstract Öz Purpose: In this study, the apoptosis marker M30, the oxidative stress markers malondialdehyde, (MDA) and asymmetric dimethyl arginine (ADMA) have been studied in the context of endometriosis. Materials ... -
TOOLS AND GEARS FOR METABOLOMICS ANALYSIS
(2023)Since its initiation within the late 1990s, metabolomics has made a critical advance as a profound phenotyping device. Metabolomics is displayed with expanded dimensionality (2D and 3D) and high-resolution expository stages ... -
Investigating the effect of ribavirin treatment on genetic mutations in Crimean-Congo haemorrhagic fever virus (CCHFV) through next-generation sequencing.
(2023)Crimean-Congo haemorrhagic fever (CCHF) is the most widespread tick-borne viral haemorrhagic fever affecting humans, and yet a licensed drug against the virus (CCHFV) is still not available. While several studies have ... -
Equilibrium and DFT modeling studies for the biosorption of Safranin O dye from water samples using Bacillus subtilis biosorbent
(2023)© 2022 Elsevier B.V.Current study deals with the biosorption of Safranin O dye from water by using high potential Bacillus subtilis biosorbent material. The presence of functional groups and surface morphology of biosorbent ... -
Removal of Erythrosine B dye from wastewater by Penicillium italicum: experimental, DFT, and molecular docking studies
(2023)The study involved the adsorption of Erythrosine B onto the dead, dry, and unmodified Penicillium italicum cells and the analytical, visual, theoretical assessment of the adsorbent-adsorbate interactions. It also included ...