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dc.contributor.authorKaya T.T.
dc.contributor.authorAltun A.
dc.contributor.authorTurgut N.H.
dc.contributor.authorAtaseven H.
dc.contributor.authorKoyluoglu G.
dc.descriptionAsian Pacific Organization for Cancer Preventionen_US
dc.description.abstractIn the present study, we investigated the effects of motesanib (AMG 706), a multikinase inhibitor alone and in combination with DuP-697, an irreversible selective inhibitor of COX-2, on cell proliferation, angiogenesis, and apoptosis induction in a human colorectal cancer cell line (HT29). Real time cell analysis (RTCA, Xcelligence system) was used to determine the effects on colorectal cancer cell proliferation. Apoptosis was assessed with annexin V staining and angiogenesis was determined with chorioallantoic membrane model. We found that motesanib alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. Combination with DUP-697 increased the antiproliferative, antiangiogenic and apoptotic effects. Results of this study indicate that motesanib may be a good choice in treatment of colorectal tumors. In addition, the increased effects of combination of motesanib with DuP-697 raise the possibility of using lower doses of these drugs and therefore avoid/minimize the dose-dependent side effects generally observed.en_US
dc.description.sponsorshipTurgut, N.H.; Department of Gastroenterology, Cumhuriyet UniversityTurkey; email: nergizht@yahoo.comen_US
dc.subjectColorectal canceren_US
dc.subjectCOX-2 inhibitionen_US
dc.subjectMultikinase inhibitoren_US
dc.titleEffects of a multikinase inhibitor motesanib (AMG 706) alone and combined with the selective DuP-697 COX-2 inhibitor on colorectal cancer cellsen_US
dc.relation.journalAsian Pacific Journal of Cancer Preventionen_US
dc.contributor.departmentKaya, T.T., Department of Pharmacology, Cumhuriyet University, Sivas, Turkey -- Altun, A., Department of Pharmacology, Cumhuriyet University, Sivas, Turkey -- Turgut, N.H., Department of Gastroenterology, Cumhuriyet University, Sivas, Turkey -- Ataseven, H., Department of Pharmacology, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey -- Koyluoglu, G., Department of Pediatric Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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