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dc.contributor.authorErdoğan Ö.
dc.contributor.authorBirtekocak F.
dc.contributor.authorOryaşin E.
dc.contributor.authorAbbak M.
dc.contributor.authorDemirbolat G.M.
dc.contributor.authorPaşa S.
dc.contributor.authorÇevik Ö.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:33:02Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:33:02Z
dc.date.issued2019
dc.identifier.issn1307671X
dc.identifier.urihttps://dx.doi.org/10.18678/dtfd.482351
dc.identifier.urihttps://hdl.handle.net/20.500.12418/5675
dc.description.abstractAim: The aim of this study is to synthesize zinc oxide nanoparticles (ZnONPs) by green chemistry method and investigate anti-bacterial and anticancer effects of these nanoparticles. Material and Methods: ZnONPs were synthesized by the green chemistry method using zinc ions and aqueous artichoke leaf (Cynara scolymus) extract. Ultraviolet-visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), zetasizer and energy dispersive X-ray spectroscopy (EDX) were used to confirm the formation and characterization of ZnONPs. Antibacterial activities of ZnONPs on four different bacteria species (E. coli, S. aureus, P. aeruginosa and E. faecalis) were measured by minimal inhibitory concentration (MIC) and agar well diffusion method. Cytotoxic effects of ZnONPs on HT-29 human colon cancer cells were determined as concentration and time dependent. Results: In the UV-Vis spectrum, absorbance increase was observed in 320-335 nm range which is specific to ZnO. In the FTIR spectrum, stretching vibrations of ZnO were determined in 426 cm-1 and 540 cm-1. The particle size was 276-309 nm in SEM analysis. In the zeta-sizer measurements of ZnONPs, the particle size was 137.8 nm and the particle charge was-6.34 meV. In the antibacterial activity measurements, it was determined that synthesized nanoparticles induce inhibition of bacterial activity in E. coli and S. aureus. ZnONPs showed cytotoxic effects on HT-29 cells at concentrations higher than 10 µg/mL. Conclusion: This study showed that ZnONPs can be prepared at low cost and have potential to be used as a carrier system for new drug formulations in clinical therapies. © 2019, Duzce University Medical School. All rights reserved.en_US
dc.language.isoturen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.isversionof10.18678/dtfd.482351en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-bacterialen_US
dc.subjectColon canceren_US
dc.subjectCytotoxicityen_US
dc.subjectGreen chemistryen_US
dc.subjectZinc oxide nanoparticleen_US
dc.titleGreen synthesis, characterization, anti-bacterial and cytotoxic effects of zinc oxide nanoparticles using aqueous extract of artichoke leafs [Enginar yaprağı sulu ekstraktı kullanılarak çinko oksit nanopartiküllerinin yeşil sentezi, karakterizasyonu, anti-bakteriyel ve sitotoksik etkileri]en_US
dc.typearticleen_US
dc.relation.journalDuzce Medical Journalen_US
dc.contributor.departmentErdoğan, Ö., Adnan Menderes Üniversitesi Tıp Fakültesi Biyokimya ADAydın, Turkey -- Birtekocak, F., Adnan Menderes Üniversitesi Tıp Fakültesi Biyokimya ADAydın, Turkey -- Oryaşin, E., Adnan Menderes Üniversitesi Bilim ve Teknoloji Araştırma Uygulama MerkeziAydın, Turkey -- Abbak, M., Adnan Menderes Üniversitesi Bilim ve Teknoloji Araştırma Uygulama MerkeziAydın, Turkey -- Demirbolat, G.M., Cumhuriyet Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji AD, Sivas, Turkey -- Paşa, S., Afyon Kocatepe Üniversitesi Eğitim Fakültesi Fen Bilimleri Eğitimi AD, Afyon, Turkey -- Çevik, Ö., Adnan Menderes Üniversitesi Tıp Fakültesi Biyokimya ADAydın, Turkeyen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.endpage26en_US
dc.identifier.startpage19en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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