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dc.contributor.authorInan, Asuman
dc.contributor.authorErdem, Hakan
dc.contributor.authorElaldi, Nazif
dc.contributor.authorGulsun, Serda
dc.contributor.authorKarahocagil, Mustafa K.
dc.contributor.authorPekok, Abdullah U.
dc.contributor.authorUlug, Mehmet
dc.contributor.authorTekin, Recep
dc.contributor.authorBosilkovski, Mile
dc.contributor.authorKaya, Safak
dc.contributor.authorHaykir-Solay, Asli
dc.contributor.authorDemirdal, Tuna
dc.contributor.authorKaya, Selcuk
dc.contributor.authorSunnetcioglu, Mahmut
dc.contributor.authorSener, Alper
dc.contributor.authorTosun, Selma
dc.contributor.authorAydin, Emsal
dc.contributor.authorUral, Serap
dc.contributor.authorYamazhan, Tansu
dc.contributor.authorMuhcu, Murat
dc.contributor.authorAyaslioglu, Ergin
dc.contributor.authorBilgic-Atli, Seval
dc.contributor.authorErbay, Ayse
dc.contributor.authorErgen, Pinar
dc.contributor.authorKadanali, Ayten
dc.contributor.authorSahin, Suzan
dc.contributor.authorSahin-Horasan, Elif
dc.contributor.authorAvci, Ali
dc.contributor.authorCag, Yakup
dc.contributor.authorBeeching, Nicholas J.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:01Z
dc.date.issued2019
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.urihttps://dx.doi.org/10.1007/s10096-019-03540-z
dc.identifier.urihttps://hdl.handle.net/20.500.12418/5868
dc.descriptionWOS: 000471726700008en_US
dc.descriptionPubMed ID: 30989418en_US
dc.description.abstractBrucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p<0.001), vaginal bleeding (p<0.001), anemia (blood hemoglobin <11g/dL; p<0.001), high level of serum aspartate aminotransferase (>41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.relation.isversionof10.1007/s10096-019-03540-zen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPregnancyen_US
dc.subjectBrucellosisen_US
dc.subjectObstetricsen_US
dc.subjectAbortusen_US
dc.subjectIntrauterine fetal demiseen_US
dc.subjectRisk factorsen_US
dc.titleBrucellosis in pregnancy: results of multicenter ID-IRI studyen_US
dc.typearticleen_US
dc.relation.journalEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASESen_US
dc.contributor.department[Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, Hakan] Gulhane Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, Serda -- Kaya, Safak -- Bilgic-Atli, Seval] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karahocagil, Mustafa K.] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Pekok, Abdullah U.] Pendik Med Pk Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ulug, Mehmet] Private Umut Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Bosilkovski, Mile] Skopje Med Fac, Dept Infect Dis & Febrile Condit, Skopje, Macedonia -- [Haykir-Solay, Asli] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Demirdal, Tuna -- Ural, Serap] Katip Celebi Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Aydin, Emsal] Kafkas Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kars, Turkey -- [Yamazhan, Tansu] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Muhcu, Murat] GATA Haydarpasa Training Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Ayaslioglu, Ergin] Kirikkale Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kirikkale, Turkey -- [Erbay, Ayse] Bozok Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Yozgat, Turkey -- [Ergen, Pinar] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kadanali, Ayten] Umraniye Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Sahin, Suzan] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Avci, Ali] Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Urol, Izmir, Turkey -- [Cag, Yakup] Turkish Hlth Sci Univ, Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Beeching, Nicholas J.] Univ Liverpool Liverpool Sch Trop Med, Clin Sci, Liverpool, Merseyside, Englanden_US
dc.identifier.volume38en_US
dc.identifier.issue7en_US
dc.identifier.endpage1268en_US
dc.identifier.startpage1261en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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