VITAMIN D RECEPTOR TAQI POLYMORPHISM IS ASSOCIATED WITH HIGHER IMMUNE RESPONSE TO HEPATITIS B VACCINATION IN TURKISH DIALYSIS PATIENTS

Abstract

Introduction: We aimed to investigate the possible role of vitamin D receptor (VDR) gene TaqI, ApaI and FokI polymorphisms in immune response to Hepatitis B virus (HBV) vaccination in dialysis patients. Methods: A total of 200 patients included in the study. Genotyping was done by using PCR-RFLP method. Results: TaqI TC genotype was 2.15 times higher in responders compared to non-responders (OR: 2.15 95% CI: 1.12-4.15, p: 0.021). TaqI CC genotype was found to be 2.80 times higher in responders compared to non-responders (OR: 2.80, 95% CI: 1.09-7.16, p: 0.031). When TC and CC genotype were evaluated together, they were found to be 2.31 times higher in responders (OR: 2.31, 95% CI: 1.26-4.24, p: 0.006). Carrying the C allele was found 1.92 times higher in responders compared to non-responders (OR: 1.92, 95% CI: 1.21-3.03, p: 0.005). No statistical significance was found between responders and non-responders in terms of FokI and ApaI genotype and allele frequencies (p > 0.05). Conclusion: Results of the present study demonstrate that carrying TC and CC genotype and C allele of VDR TaqI polymorphism have showed higher vaccination response while carrying TT genotype and T allele showed lower vaccination response in dialysis patients.