dc.contributor.author | Huzmeli, Can | |
dc.contributor.author | Candan, Ferhan | |
dc.contributor.author | Bagci, Gokhan | |
dc.contributor.author | Bagci, Binnur | |
dc.contributor.author | Akkaya, Lale | |
dc.contributor.author | Seker, Ayse | |
dc.contributor.author | Kayatas, Mansur | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:39:22Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:39:22Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0393-6384 | |
dc.identifier.issn | 2283-9720 | |
dc.identifier.uri | https://dx.doi.org/10.19193/0393-6384_2018_3_121 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6517 | |
dc.description | WOS: 000434980000026 | en_US |
dc.description.abstract | Introduction: We aimed to investigate the possible role of vitamin D receptor (VDR) gene TaqI, ApaI and FokI polymorphisms in immune response to Hepatitis B virus (HBV) vaccination in dialysis patients. Methods: A total of 200 patients included in the study. Genotyping was done by using PCR-RFLP method. Results: TaqI TC genotype was 2.15 times higher in responders compared to non-responders (OR: 2.15 95% CI: 1.12-4.15, p: 0.021). TaqI CC genotype was found to be 2.80 times higher in responders compared to non-responders (OR: 2.80, 95% CI: 1.09-7.16, p: 0.031). When TC and CC genotype were evaluated together, they were found to be 2.31 times higher in responders (OR: 2.31, 95% CI: 1.26-4.24, p: 0.006). Carrying the C allele was found 1.92 times higher in responders compared to non-responders (OR: 1.92, 95% CI: 1.21-3.03, p: 0.005). No statistical significance was found between responders and non-responders in terms of FokI and ApaI genotype and allele frequencies (p > 0.05). Conclusion: Results of the present study demonstrate that carrying TC and CC genotype and C allele of VDR TaqI polymorphism have showed higher vaccination response while carrying TT genotype and T allele showed lower vaccination response in dialysis patients. | en_US |
dc.description.sponsorship | Scientific Research Project Fund of Cumhuriyet University [T-594] | en_US |
dc.description.sponsorship | This work was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number 'T-594' | en_US |
dc.language.iso | eng | en_US |
dc.publisher | CARBONE EDITORE | en_US |
dc.relation.isversionof | 10.19193/0393-6384_2018_3_121 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hemodialysis | en_US |
dc.subject | peritoneal dialysis | en_US |
dc.subject | vitamin D receptor | en_US |
dc.subject | chronic kidney disease | en_US |
dc.subject | vitamin D | en_US |
dc.subject | polymorphism | en_US |
dc.title | VITAMIN D RECEPTOR TAQI POLYMORPHISM IS ASSOCIATED WITH HIGHER IMMUNE RESPONSE TO HEPATITIS B VACCINATION IN TURKISH DIALYSIS PATIENTS | en_US |
dc.type | article | en_US |
dc.relation.journal | ACTA MEDICA MEDITERRANEA | en_US |
dc.contributor.department | [Huzmeli, Can -- Candan, Ferhan -- Akkaya, Lale -- Seker, Ayse -- Kayatas, Mansur] Cumhuriyet Univ, Dept Nephrol, Fac Med, Sivas, Turkey -- [Bagci, Gokhan] Cumhuriyet Univ, Dept Med Genet, Fac Med, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Dept Nutr & Dietet, Fac Hlth Sci, Sivas, Turkey | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 796 | en_US |
dc.identifier.startpage | 791 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |