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dc.contributor.authorSari, Ismail
dc.contributor.authorPinarbasi, Hatice
dc.contributor.authorPinarbasi, Ergun
dc.contributor.authorYildiz, Caglar
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:09Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:09Z
dc.date.issued2017
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.urihttps://dx.doi.org/10.1080/10641955.2017.1388390
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6942
dc.descriptionWOS: 000418577600006en_US
dc.descriptionPubMed ID: 29058492en_US
dc.description.abstractObjective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.Methods: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively.Results: The presence of the K55R polymorphism was significantly higher in cases (28.1%) than controls (17.3%), and was associated with increased risk of PE (OR: 1.86; 95% CI: 1.09-2.63). Methylation levels of the EPHX2 promoter region in cases were significantly lower than controls. A 2.83 times increased PE risk was observed in pregnant women with EPHX2 promoter methylation levels of <25% (OR: 2.83; 95% CI: 1.15-6.91).Conclusion: In conclusion, hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of PE. sEH enzyme may play a role in the pathogenesis of PE by contributing to reduction of the vasodilatator, anti-hypertensive, and anti-inflammatory effects of EETs by rapid degradation of these molecules.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [T-551]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Cumhuriyet University (grant number T-551).en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.isversionof10.1080/10641955.2017.1388390en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSoluble epoxide hydrolaseen_US
dc.subjectgenetic polymorphismen_US
dc.subjectepoxyeicosatrienoic aciden_US
dc.subjectmethylationen_US
dc.titleAssociation between the soluble epoxide hydrolase gene and preeclampsiaen_US
dc.typearticleen_US
dc.relation.journalHYPERTENSION IN PREGNANCYen_US
dc.contributor.department[Sari, Ismail] Nigde Omer Halisdemir Univ, Sch Med, Dept Med Biochem, Nigde, Turkey -- [Pinarbasi, Hatice] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Pinarbasi, Ergun] Cumhuriyet Univ, Sch Med, Dept Med Biol, Sivas, Turkey -- [Yildiz, Caglar] Cumhuriyet Univ, Sch Med, Dept Gynecol & Obstet, Sivas, Turkeyen_US
dc.contributor.authorIDSari, Ismail -- 0000-0003-3732-2102en_US
dc.identifier.volume36en_US
dc.identifier.issue4en_US
dc.identifier.endpage325en_US
dc.identifier.startpage315en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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