Show simple item record

dc.contributor.authorYuce, Hatice Balci
dc.contributor.authorKaratas, Ozkan
dc.contributor.authorTurkal, Humeyra Aydemir
dc.contributor.authorGorgun, Emine Pirim
dc.contributor.authorOcakli, Seda
dc.contributor.authorBenli, Ismail
dc.contributor.authorCaylii, Sevil
dc.descriptionWOS: 000375842800001en_US
dc.descriptionPubMed ID: 26654347en_US
dc.description.abstractBackground: The aim of this study examines the effect of systemic melatonin administration on proin-flammatory cytokine levels, apoptosis, alveolar bone loss (ABL), lipid metabolism, and diabetic control in in rats with diabetes mellitus (DM) and ligature-induced periodontitis. Methods: Fifty-two male Wistar rats were used in this study. Study groups were as follows: 1) non-ligated control (NL, n = 6); 2) streptozotocin (STZ, n = 8); 3) STZ and melatonin (STZ+Mel, n = 8); 4) ligature (L, n = 6); 5) ligature and melatonin (L+Mel, n = 8); 6) STZ and ligature (STZ+L, n = 8); and 7) STZ, ligature, and melatonin (STZ+L+Mel, n = 8). DM was induced by intraperitoneal injection of a single dose of STZ (60 mg/kg). Melatonin was administered by intraperitoneal injection of a dose of 10 mg/kg/day for 4 weeks. Silk ligatures were placed subgingivally around the mandibular right first molars. The study period was 4 weeks, and animals were sacrificed at the end of 4 weeks. Morphometric analysis of bone loss was performed. Tissues were histopathologically examined. Inducible nitric oxide synthase (iNOS) and B-cell lymphoma-2-associated X (bax) protein expressions, serum interleukin (IL)-1 beta levels, and tartrate-resistant acid phosphatase-positive (TRAP+) osteoclast numbers were also evaluated. Results: After 4 weeks, the highest ABL was observed in the STZ+L group, and the difference was significant (P < 0.05). Systemically administered melatonin significantly decreased ABL in the STZ+L+Mel group compared with that in the STZ+L group (P < 0.05). TRAP+ osteoclast numbers were the highest in the STZ+L group, and melatonin significantly decreased osteoclast numbers (P < 0.05) but had no effect on iNOS, IL-1 beta, or bax levels. Conclusions: Within the limits of this study, it can be concluded that systemic melatonin treatment may decrease osteoclastic activity and reduce ABL in the model using rats with DM.en_US
dc.description.sponsorshipGaziosmanpasa University's Unit of Scientific Research Projectsen_US
dc.description.sponsorshipNo external funding other than the support of the Gaziosmanpasa University's Unit of Scientific Research Projects was provided for this study. The authors report no conflicts of interest related to this study.en_US
dc.subjectExperimental diabetes mellitusen_US
dc.titleThe Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitisen_US
dc.contributor.department[Yuce, Hatice Balci -- Karatas, Ozkan -- Turkal, Humeyra Aydemir] Gaziosmanpasa Univ, Dept Periodontol, Fac Dent, TR-60100 Tokat, Turkey -- [Gorgun, Emine Pirim] Cumhuriyet Univ, Dept Periodontol, Fac Dent, Sivas, Turkey -- [Ocakli, Seda] Gaziosmanpasa Univ, Fac Med, Dept Histol & Embryol, TR-60100 Tokat, Turkey -- [Benli, Ismail] Gaziosmanpasa Univ, Fac Med, Dept Biochem, TR-60100 Tokat, Turkey -- [Caylii, Sevil] Yildirim Beyazit Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record