| dc.contributor.author | Senkardes, Sevil | |
| dc.contributor.author | Ozakpinar, Ozlem B. | |
| dc.contributor.author | Ozsavci, Derya | |
| dc.contributor.author | Sener, Azize | |
| dc.contributor.author | Cevik, Ozge | |
| dc.contributor.author | Kucukguzel, S. Guniz | |
| dc.date.accessioned | 2019-07-27T12:10:23Z | |
| dc.date.accessioned | 2019-07-28T09:47:04Z | |
| dc.date.available | 2019-07-27T12:10:23Z | |
| dc.date.available | 2019-07-28T09:47:04Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1871-5206 | |
| dc.identifier.issn | 1875-5992 | |
| dc.identifier.uri | https://dx.doi.org/10.2174/1871520615666150831125337 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/7621 | |
| dc.description | WOS: 000382267900005 | en_US |
| dc.description | PubMed ID: 26320814 | en_US |
| dc.description.abstract | A series of diflunisal 4-thiazolidinones were synthesized. Some selected compounds were determined at one dose towards the full panel of 60 human cancer cell lines by National Cancer Institute. 2',4'-Difluoro-4-hydroxy-N-[4-oxo-2-(thiophen-2-yl)-1,3-thiazolidin-3-yl]biphenyl-3-carboxamide (4a) demonstrated the most marked effect on K-562 cancer cell line with 58.59 % growth inhibition at 10 mu M. Compound 4a was evaluated in vitro using the MTT colorimetric method against human leukemia cell line K-562 and mouse embryonic fibroblasts cell line NIH-3T3 at different doses for cell viability and growth inhibition. Compound 4a exhibited anticancer activity with IC50 value of 5.2 mu M against K-562 cells and did not display cytotoxicity towards NIH-3T3 cells compared with diflunisal. In addition, this compound could be an interesting prototype as an antiproliferative agent. | en_US |
| dc.description.sponsorship | Scientific and Technical Research Council of Turkey (TUBITAK), Research Fund Project [112S013] | en_US |
| dc.description.sponsorship | This research was supported by The Scientific and Technical Research Council of Turkey (TUBITAK), Research Fund Project Number: 112S013. The authors are grateful to Dr. Jurgen Gross from the Institute of Organic Chemistry, University of Heidelberg, for his generous help on obtaining HR-EI/DART mass spectra of the synthesized compounds. We thank the Division of Cancer Research, National Cancer Institute, Bethesda, MD, USA, for the anticancer activity screening. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | BENTHAM SCIENCE PUBL LTD | en_US |
| dc.relation.isversionof | 10.2174/1871520615666150831125337 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Annexin-V | en_US |
| dc.subject | apoptosis | en_US |
| dc.subject | diflunisal | en_US |
| dc.subject | K-562 cancer cell line | en_US |
| dc.subject | 4-Thiazolidinone | en_US |
| dc.title | Synthesis of Diflunisal Thiazolidinones as Anticancer Agents | en_US |
| dc.type | article | en_US |
| dc.relation.journal | ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | en_US |
| dc.contributor.department | [Senkardes, Sevil -- Kucukguzel, S. Guniz] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey -- [Ozakpinar, Ozlem B. -- Ozsavci, Derya -- Sener, Azize -- Cevik, Ozge] Marmara Univ, Fac Pharm, Dept Biochem, TR-34668 Istanbul, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey | en_US |
| dc.contributor.authorID | Cevik, Ozge -- 0000-0002-9325-3757 | en_US |
| dc.identifier.volume | 16 | en_US |
| dc.identifier.issue | 10 | en_US |
| dc.identifier.endpage | 1274 | en_US |
| dc.identifier.startpage | 1266 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
