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Isolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015)
Toxoplasma gondii is an intracellular parasitic protozoon which infects human and most warm-blooded animals. Almost one-third of the world's population is affected by life-threatening infection of T. gondii tachyzoites ...
Heat Shock Proteins; An Overview
(BENTHAM SCIENCE PUBL LTD, 2010)
Heat shock proteins (Hsps) protect protein substrates against conformational damage to promote the function of the proteins, prevent aggregation and prevent formation of toxic inclusion bodies. Protein aggregates and fibrils ...
Determination of Optimum Operation Parameters for Low-Intensity Pulsed Ultrasound and Low-Level Laser Based Treatment to Induce Proliferation of Osteoblast and Fibroblast Cells
(MARY ANN LIEBERT, INC, 2018)
Objective: The aim of this study was to determine the optimum operating parameters (pulse duration, energy levels, and application time) to promote induction of osteoblast and fibroblast cell proliferation and to maintain ...
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)
Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and ...
CRP subunit association and hinge conformation changes in response to cAMP binding: Analysis of C-helix cysteine-substituted CRP
(AMER CHEMICAL SOC, 2006)
We investigated the characteristics of 13 CRP variants having cysteine substituted at positions 113, 115, 116, 117, 118, 120, 122, 124, 126, 127, 129, 130, or 131, positions that span the length of the CRP C alpha-helix. ...
Heat Shock Protein 90 Inhibitors in Oncology
(BENTHAM SCIENCE PUBL LTD, 2014)
Heat shock protein 90 (Hsp90) is highly conserved chaperone protein which plays vital roles in stabilization, regulation and folding of client proteins in cancer cells. Client proteins are key macromolecules for carcinogenesis ...
Chemical linkage at allosteric activation of E-Coli cAMP receptor protein
(SPRINGER, 2008)
Cyclic AMP Receptor protein (CRP) regulates transcription initiation in E. coli. The ligand and DNA binding data yields the following results: (1) There are two different types of cAMP binding sites; weak and strong. (2) ...
MicroRNAs and Cancer; an Overview
(BENTHAM SCIENCE PUBL LTD, 2014)
MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known ...
A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
(BENTHAM SCIENCE PUBL LTD, 2015)
Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase ...
Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands
(SPRINGER, 2017)
Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against ...