Polymorphisms of selected genes related to increased cardiovascular risk in patients with acute coronary syndromes and their relation to the severity of coronary artery disease
Inanc, Mehmet Tugrul
Eryol, Namik Kemal
MetadataShow full item record
Background: beta-Fibrinogen 455G/A, factor V 1691G/A, 1299H/A and glycoprotein Ilb/IIla PL A1/A2 polymorphisms are tought to be related to arterial thrombotic disorders, especially coronary artery disease (CAD) and myocardial infarction (MI). Aim: The aims of this study were to investigate the frequencies of these polymorphisms in subgroups of acute coronary syndromes (ACS) and the effects of these polymorphisms on the angiographic findings of patients with ACS. Material and methods: The study included 35 patients (mean age 61 years) diagnosed with ACS who underwent coronary angiography. The patients with ST elevation MI comprised group I and patients without ST elevation comprised group II. Results: The groups were not different regarding clinical properties of patients and CAD risk factors. The numbers of patients with beta-fibrinogen 455A, factor V 1691A and 1299A, and glycoprotein Ilb/IIla PL A2 alleles were 7 (46.7%) and 8 (40%), 3 (20%) and 4 (20%), 3 (20%) and 3 (15%), and 3 (20%) and 5 (25%), in groups I and II respectively (p = 0.69, p = 1.0, p = 0.69, p = 0.72, respectively). Angiographic findings were not related to these polymorphisms. Conclusions: We did not find any relation among ACS subtype and angiographic severity of coronary atherosclerosis with beta-fibrinogen 455G/A, factor V 1691G/A, 1299H/A and glycoprotein Ilb/IIla PL A1/A2 polymorphisms. These findings suggest that these polymorphisms have no effects on the relative magnitude of thrombus responsible for ACS or the severity of the occlusion of the coronary artery related ACS. Future studies with larger groups may reveal whether these genetic alterations have a significant impact on ACS.