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dc.contributor.authorGul, Ibrahim
dc.contributor.authorKucukdurmaz, Zekeriya
dc.contributor.authorKalay, Nihat
dc.contributor.authorKarapinar, Hekim
dc.contributor.authorInanc, Mehmet Tugrul
dc.contributor.authorOzdogru, Ibrahim
dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorEryol, Namik Kemal
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:04:02Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:04:02Z
dc.date.issued2012
dc.identifier.issn1734-9338
dc.identifier.issn1897-4295
dc.identifier.urihttps://dx.doi.org/10.5114/pwki.2012.27922
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9218
dc.descriptionWOS: 000302895000005en_US
dc.description.abstractBackground: beta-Fibrinogen 455G/A, factor V 1691G/A, 1299H/A and glycoprotein Ilb/IIla PL A1/A2 polymorphisms are tought to be related to arterial thrombotic disorders, especially coronary artery disease (CAD) and myocardial infarction (MI). Aim: The aims of this study were to investigate the frequencies of these polymorphisms in subgroups of acute coronary syndromes (ACS) and the effects of these polymorphisms on the angiographic findings of patients with ACS. Material and methods: The study included 35 patients (mean age 61 years) diagnosed with ACS who underwent coronary angiography. The patients with ST elevation MI comprised group I and patients without ST elevation comprised group II. Results: The groups were not different regarding clinical properties of patients and CAD risk factors. The numbers of patients with beta-fibrinogen 455A, factor V 1691A and 1299A, and glycoprotein Ilb/IIla PL A2 alleles were 7 (46.7%) and 8 (40%), 3 (20%) and 4 (20%), 3 (20%) and 3 (15%), and 3 (20%) and 5 (25%), in groups I and II respectively (p = 0.69, p = 1.0, p = 0.69, p = 0.72, respectively). Angiographic findings were not related to these polymorphisms. Conclusions: We did not find any relation among ACS subtype and angiographic severity of coronary atherosclerosis with beta-fibrinogen 455G/A, factor V 1691G/A, 1299H/A and glycoprotein Ilb/IIla PL A1/A2 polymorphisms. These findings suggest that these polymorphisms have no effects on the relative magnitude of thrombus responsible for ACS or the severity of the occlusion of the coronary artery related ACS. Future studies with larger groups may reveal whether these genetic alterations have a significant impact on ACS.en_US
dc.language.isoengen_US
dc.publisherTERMEDIA PUBLISHING HOUSE LTDen_US
dc.relation.isversionof10.5114/pwki.2012.27922en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacute coronary syndromeen_US
dc.subjectcoagulation proteinen_US
dc.subjectgenesen_US
dc.subjectpolymorphismen_US
dc.titlePolymorphisms of selected genes related to increased cardiovascular risk in patients with acute coronary syndromes and their relation to the severity of coronary artery diseaseen_US
dc.typearticleen_US
dc.relation.journalPOSTEPY W KARDIOLOGII INTERWENCYJNEJen_US
dc.contributor.department[Gul, Ibrahim -- Kucukdurmaz, Zekeriya -- Karapinar, Hekim -- Yilmaz, Ahmet] Cumhuriyet Univ, Sch Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Kalay, Nihat -- Inanc, Mehmet Tugrul -- Ozdogru, Ibrahim -- Eryol, Namik Kemal] Erciyes Univ, Sch Med, Dept Cardiol, Kayseri, Turkeyen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.endpage30en_US
dc.identifier.startpage25en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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