dc.contributor.author | Katrancioglu, Nurkay | |
dc.contributor.author | Karahan, Oguz | |
dc.contributor.author | Kilic, Ahmet Turhan | |
dc.contributor.author | Katrancioglu, Ozgur | |
dc.contributor.author | Celik, Cem | |
dc.contributor.author | Bakici, Mustafa Zahir | |
dc.contributor.author | Atahan, Erhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:04:10Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:04:10Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1996-0808 | |
dc.identifier.uri | https://dx.doi.org/10.5897/AJMR11.1084 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9256 | |
dc.description | WOS: 000306480900013 | en_US |
dc.description.abstract | Prosthetic vascular graft infection remains one of the most serious complications seen after vascular surgery. Recently, fibrin glue has gained attention as a possible means to deliver drug therapies. In this study, the efficacy of vancomycin incorporated fibrin glue for preventing methicillin-resistant Staphylococcus aureus (MRSA) infection of prosthetic grafts was investigated. The vascular grafts were implanted into subcutaneous pockets in the backs of 32 rats. Group 1: no graft contamination; Group 2: MRSA contamination; Group 3: vancomycin incorporated fibrin glue graft and MRSA contamination; and Group 4: vancomycin soaked graft and MRSA contamination. The grafts were removed after 7 days and evaluated by a quantitative culture analysis. The quantitative culture values for Groups 2, 3, and 4 were 1.8x10(11) +/- 1.4x10(11), 1.1x10(7) +/- 2.4x10(7), and 2.6x10(8) +/- 3.9x10(8), respectively. The culture values of the Group 2 was significantly higher than those of the Group 3 and Group 4 (p=0.014 and p=0.016, respectively), however, Groups 3 and 4 were comparable (p=0.161). In our study, efficacies of vancomycin-incorporated fibrin and vancomycin alone were comparable. The finding of the current study indicated that a fibrin-based delivery system might not be as effective an option as a vancomycin delivery. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ACADEMIC JOURNALS | en_US |
dc.relation.isversionof | 10.5897/AJMR11.1084 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Vascular graft infection | en_US |
dc.subject | fibrin glue | en_US |
dc.subject | methicillin-resistant Staphylococcus aureus (MRSA) | en_US |
dc.title | Is sustained release of vancomycin from fibrin glue effective to prevent methicillin-resistant Staphylococcus aureus graft infection? | en_US |
dc.type | article | en_US |
dc.relation.journal | AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | en_US |
dc.contributor.department | [Katrancioglu, Nurkay -- Karahan, Oguz -- Kilic, Ahmet Turhan -- Atahan, Erhan] Cumhuriyet Univ, Sch Med, Dept Cardiovasc Surg, TR-58140 Sivas, Turkey -- [Katrancioglu, Ozgur] Numune State Hosp, Dept Thorac Surg, TR-58050 Sivas, Turkey | en_US |
dc.contributor.authorID | Karahan, Oguz -- 0000-0003-0044-9476 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 801 | en_US |
dc.identifier.startpage | 798 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |