Risk factors of radiation pneumonitis in patients with NSCLC treated with concomitant chemoradiotherapy--Are we underestimating diabetes?--Turkish oncology group (TOG)/Lung cancer study group

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dc.authoridDINCBAS, HIDAYET FAZILET/0000-0002-4764-9419
dc.authoridErgen, Sefika Arzu/0000-0002-7819-2335
dc.authoridAkyurek, Serap/0000-0001-8840-0233
dc.authoridaltinok, pelin/0000-0001-5970-6452
dc.authoridYucel, Birsen/0000-0002-0083-6866
dc.authoridKILIC, Diclehan/0000-0002-6568-0866
dc.contributor.authorErgen, Sefika A.
dc.contributor.authorDincbas, Fazilet O.
dc.contributor.authorYucel, Birsen
dc.contributor.authorAltinok, Pelin
dc.contributor.authorAkyurek, Serap
dc.contributor.authorKirakli, Esra Korkmaz
dc.contributor.authorUlger, Sukran
dc.date.accessioned2024-10-26T18:11:31Z
dc.date.available2024-10-26T18:11:31Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction To evaluate the clinical and dosimetric parameters that increase the risk of radiation pneumonitis (RP) in locally advanced non-small cell lung cancer (NSCLC) patients treated with concomitant chemoradiotherapy of nationwide multicentric data analysis. Methods All data of 268 patients who underwent definitive chemoradiotherapy were retrospectively collected from eight institutes participating in this study. Patient, tumor and treatment-related factors and dosimetric parameters were analyzed for grade >= 2 RP. The toxicity scoring system of The Radiation Therapy Oncology Group used for grading the severity of pneumonitis. A relationship with the risk of RP with potential predictive factors were evaluated by univariate and multivariate analyses. A recursive partition analysis (RPA) was applied to stratify patients according to the risk of developing RP. Results There were 90 (33.6%) patients who had grade >= 2 RP. The median time to pneumonitis after treatment was 4 months (range:1-6 months). In univariate analysis, diabetes mellitus (DM), use of cisplatin/etoposide, total and daily radiotherapy (RT) fraction dose, the planning target volume (PTV) size, mean lung dose, V5, V10 and RT technique were associated with the development of pneumonitis. In multivariate analysis, only DM (P = 0.008) was found to be independent risk factors for RP. According to RPA, the risk of developing RP was highest in patients with DM. Conclusions In our study, besides the known dosimetric factors, DM was found to be the most important risk factor causing RP development in multivariate analysis and RPA. The risk is tripled compared to patients without DM.
dc.identifier.doi10.1111/crj.13220
dc.identifier.endpage879
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue9
dc.identifier.pmid32470205
dc.identifier.scopus2-s2.0-85087212052
dc.identifier.scopusqualityQ3
dc.identifier.startpage871
dc.identifier.urihttps://doi.org/10.1111/crj.13220
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30709
dc.identifier.volume14
dc.identifier.wosWOS:000541899500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes Mellitus
dc.subjectdose-volume histogram
dc.subjectlung cancer
dc.subjectradiation pneumonitis
dc.subjectRT
dc.titleRisk factors of radiation pneumonitis in patients with NSCLC treated with concomitant chemoradiotherapy--Are we underestimating diabetes?--Turkish oncology group (TOG)/Lung cancer study group
dc.typeArticle

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