Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients

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dc.authoridYAGMUR, ISIL/0000-0002-7009-4693
dc.authoridAltun, Ahmet/0000-0003-2056-8683
dc.contributor.authorOrak, Yavuz
dc.contributor.authorTolun, Fatma Inanc
dc.contributor.authorBakacak, Murat
dc.contributor.authorYaylali, Asli
dc.contributor.authorKiran, Hakan
dc.contributor.authoroksuz, Hafize
dc.contributor.authorDoganer, Adem
dc.date.accessioned2024-10-26T18:08:09Z
dc.date.available2024-10-26T18:08:09Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground. Pain aggravates the autonomic response to stress and raises neuroendocrine stress hormone levels. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. A prospective, randomized, and controlled trial was conducted with 60 patients. Methods. We randomly allocated patients to groups P (remifentanil/propofol, n = 30) and S (remifentanil/sevoflurane, n = 30). Preoperative blood samples were taken to measure serum adrenocorticotropic hormone (ACTH), corticotropin-releasing hormone (CRH), glucagon, cortisol, aldosterone, and prostaglandin E2 (PGE2) levels. Intraoperatively and postoperatively, clinical parameters were monitored at different time points. The hormone levels were again measured in the follicular fluid and blood postoperatively. Result. Demographic data were similar. The preoperative serum aldosterone levels were significantly higher in group P (p=0.001). Preoperative and postoperative serum ACTH, glucagon, cortisol, and PGE2 levels were significantly different in group P (p=0.009, p=0.004, p=0.029, and p=0.002); serum ACTH, glucagon, and PGE2 levels increased while serum cortisol levels decreased postoperatively. In group S, serum CRH and aldosterone levels, both increased in the postoperative period compared to the preoperative (p=0.001, p=0.006). Postoperatively, glucagon and PGE2 levels were both higher in group P than group S (p=0.019, p=0.015). In postoperative follicular fluid, glucagon and PGE2 levels were higher in group P, while cortisol levels were higher in group S (p=0.001, p=0.007, and p=0.001). Conclusion. The effects of anesthetic agents were different. In group P, in the preoperative and postoperative evaluation, ACTH, glucagon, and PGE2 increased postoperatively, while cortisol decreased. In group S, aldosterone and CRH increased postoperatively. Glucagon and PG E2 were higher in group P than S, postoperatively.
dc.description.sponsorshipKahramanmaras Sutcu Imam University Scientific Research Projects [2018/2-46M]
dc.description.sponsorshipThe authors would like to thank Enago (http://www.enago.com) for the English language review. The authors would like to thank Kahramanmaras Sutcu Imam University Scientific Research Projects Unit. The work was supported by Kahramanmaras Sutcu Imam University Scientific Research Projects (Project no. 2018/2-46M).
dc.identifier.doi10.1155/2021/5517150
dc.identifier.issn1203-6765
dc.identifier.issn1918-1523
dc.identifier.pmid33936350
dc.identifier.scopus2-s2.0-85105275731
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2021/5517150
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29843
dc.identifier.volume2021
dc.identifier.wosWOS:000646721200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofPain Research & Management
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEffects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients
dc.typeArticle

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