Evaluation of potential cytotoxic and apoptotic effects of paclitaxel and docetaxel in human Burkitt lymphoma cell lines

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dc.authoridkarademir, mustafa/0000-0002-0734-9040
dc.contributor.authorAltun, Ahmet
dc.contributor.authorKarademir, Mustafa
dc.contributor.authorAltun, Guelsah
dc.date.accessioned2024-10-26T18:07:19Z
dc.date.available2024-10-26T18:07:19Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: To study the cytotoxicity of paclitaxel and docetaxel on cell viability and apoptosis in Burkitt lymphoma cell lines.Methods: The cytotoxic activity of Paclitaxel and Docetaxel against Burkitt lymphoma cells was evaluated using the XTT cell viability test. The cells were exposed to increasing concentrations of paclitaxel and docetaxel ranging from 0.0001 to 10 mu M for 48 h. Cell cycle analysis and apoptosis were also assessed using flow cytometry-based experiments.Results: Both paclitaxel and docetaxel exhibited a concentration-dependent cytotoxic effect with IC50 of 5.32 and 6.58 mu M, respectively. Furthermore, paclitaxel and docetaxel were shown to have a significant apoptotic effect on Burkitt lymphoma cells (p < 0.01). Furthermore, paclitaxel and docetaxel arrested Burkitt lymphoma cells at the G2/M phase.Conclusion: Paclitaxel and docetaxel are potential candidates for the treatment of Burkitt lymphoma. Since both drugs are already licensed for many indications, the addition of Burkitt lymphoma to the list of indications of these drugs would be a much easier and faster process. However, there is a need for further in vitro and in vivo research to fully elucidate their mechanisms of action.
dc.identifier.doi10.4314/tjpr.v21i11.15
dc.identifier.endpage2378
dc.identifier.issn1596-5996
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85143618887
dc.identifier.scopusqualityQ3
dc.identifier.startpage2375
dc.identifier.urihttps://doi.org/10.4314/tjpr.v21i11.15
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29453
dc.identifier.volume21
dc.identifier.wosWOS:000906990700015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPharmacotherapy Group
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBurkitt lymphoma
dc.subjectPaclitaxel
dc.subjectDocetaxel
dc.subjectApoptosis
dc.subjectCytotoxicity
dc.titleEvaluation of potential cytotoxic and apoptotic effects of paclitaxel and docetaxel in human Burkitt lymphoma cell lines
dc.typeArticle

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