Teratogenic and Neurotoxic Effects of n-Butanol on Zebrafish Development

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dc.authoridCOMAKLI, Selim/0000-0002-8744-7686
dc.contributor.authorKokturk, Mine
dc.contributor.authorComakli, Selim
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorAlak, Gonca
dc.contributor.authorAtamanalp, Muhammed
dc.date.accessioned2024-10-26T18:07:37Z
dc.date.available2024-10-26T18:07:37Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn recent years, n-butanol, a type of alcohol, has been widely used from the chemical industry to the food industry. In this study, toxic effects of n-butanol's different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L) in Zebrafish Danio rerio embryos and larvae were investigated. For this purpose, Zebrafish embryos were exposed to n-butanol in acute semistatic applications. Teratogenic effects such as cardiac edema, scoliosis, lordosis, head development abnormality, yolk sac edema, and tail abnormality were determined at different time intervals (24, 48, 72, 96, and 120 h). Additionally, histopathological abnormalities such as vacuole formation in brain tissue and necrosis in liver tissue were observed at high doses (500, 750, and 1,000 mg/L) in all treatment groups at 96 h. It was determined that heart rate decreased at 48, 72, and 96 h due to an increase in concentration. In addition, alcohol-induced eye size reduction (microphthalmia) and single eye formation (cyclopia) are also among the effects observed in our research findings. In conclusion, n-butanol has been observed to cause intense neurotoxic, teratogenic, and cardiotoxic effects in Zebrafish embryos and larvae.
dc.identifier.doi10.1002/aah.10123
dc.identifier.endpage106
dc.identifier.issn0899-7659
dc.identifier.issn1548-8667
dc.identifier.issue2
dc.identifier.pmid33780052
dc.identifier.scopus2-s2.0-85103182166
dc.identifier.scopusqualityQ2
dc.identifier.startpage94
dc.identifier.urihttps://doi.org/10.1002/aah.10123
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29585
dc.identifier.volume33
dc.identifier.wosWOS:000634326000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Aquatic Animal Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleTeratogenic and Neurotoxic Effects of n-Butanol on Zebrafish Development
dc.typeArticle

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