Pre-treatment and post-treatment changes in platelet indices in patients with immune thrombocytopenia

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dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorUslu, Ali U.
dc.contributor.authorAydin, Bahattin
dc.contributor.authorDogan, Ozgur
dc.contributor.authorSencan, Mehmet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:59:33Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:59:33Z
dc.date.issued2013
dc.department[Korkmaz, Serdal -- Sencan, Mehmet] Cumhuriyet Univ, Dept Hematol, TR-58140 Sivas, Turkey -- [Uslu, Ali U. -- Aydin, Bahattin -- Dogan, Ozgur] Cumhuriyet Univ, Dept Internal Med, TR-58140 Sivas, Turkeyen_US
dc.description.abstractObjectives: To investigate if there is a correlation between pre- and post-treatment mean platelet volume (MPV), platelet size deviation width (PDW), and platecrit (PCT) values and to investigate whether we can use them as laboratory parameters to estimate the relapses of immune thrombocytopenia (ITP) patients. Methods: Patients with ITP diagnosed at the Hematology Clinic, School of Medicine, Cumhuriyet University, Sivas, Turkey between January 2005 and December 2011 were evaluated by a retrospective review of our patients' records. Eighty-one patients with ITP were collected. The first relapse was termed as the hospitalization day before second-line therapy, and the second relapse was termed as the hospitalization day before alternate second-line therapy. We provided the following data of ITP patients at diagnosis, before and after first relapses, and before and after second relapses: presenting symptoms, platelet count, MPV, PDW, and PCT values. Results: We obtained significant statistical differences between MPV values after initial treatment and before second-line therapy (first relapse) (p=0.005), between MPV values after splenectomy and before immunosuppressive or immune modulator therapy (second relapse) (p=0.028), and also, between PCT values after splenectomy and before second relapse (p=0.043). Conclusion: Mean platelet volume is gradually increasing before first and second relapses, and again normal values are being obtained after appropriate therapies. We conclude that MPV is a useful parameter as a predictor of relapses.en_US
dc.identifier.endpage596en_US
dc.identifier.issn0379-5284
dc.identifier.issue6en_US
dc.identifier.pmid23756923en_US
dc.identifier.scopus2-s2.0-84879148701en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage591en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8670
dc.identifier.volume34en_US
dc.identifier.wosWOS:000326873900004en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAUDI MED Jen_US
dc.relation.ispartofSAUDI MEDICAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePre-treatment and post-treatment changes in platelet indices in patients with immune thrombocytopeniaen_US
dc.typeArticleen_US

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