Doxorubucin loaded pH-responsive chitosan-poly(acrylamide-maleic acid) composite hydrogel for anticancer targeting

Basit Öğe Kaydı
dc.authorid0000-0001-9139-1884tr
dc.contributor.authorAkkaya, Birnur
dc.contributor.authorAkkaya, Recep
dc.contributor.authorÇelikkaya, Sümeyye İdil
dc.contributor.authorsarıaydın, Nurgül
dc.contributor.authorRaheem, K.Y.
dc.date.accessioned2024-02-27T11:56:19Z
dc.date.available2024-02-27T11:56:19Z
dc.date.issued2023tr
dc.departmentFen Fakültesitr
dc.description.abstract© 2022 Elsevier B.V.A pH responsive superadsorbent composite hydrogel, chitosan-poly(acrylamide-maleic acid)(Ch-p(Ac-Ma)), were synthesized, characterized and loaded by Doxorubucin (Dox), anti-cancer drug. Chitosan solution was modified by blending biocompatible chitosan and poly(acrylamide-co-maleic acid) in the polymerization medium. This new composite hydrogel had a high loading capacity for Dox (∼90%). Some chemical characteristics of the prepared composite hydrogel were investigated by swelling test, SEM, FTIR, XRD. The drug release study confirmed the pH-responsive delivery of doxorubucin. The composite hydrogel was loaded by high efficiency and the release experiments exhibited that Dox is released more at pH 4.5 compared with pH 7.4 at 37 °C. The biocompatibility of the prepared composite hydrogel was demonstrated via XTT assay in MCF-7 cells. The Dox loaded composite showed a controlled release, especially at acidic region. The Ch-p(Ac-Ma) exhibited a good biocompatibility against breast cancer cells (MCF 7) and dose dependent drug delivery behavior. Also, we employed molecular docking and density functional theory analysis to investigate the inhibitory activity, reactivity, and stability of Doxorubucin and target protein HER2 ((Pdb ID: 7JXH). The interaction between Doxorubucin and target protein HER2 ((Pdb ID: 7JXH) was investigated in the light of Molecular Docking calculations.tr
dc.description.sponsorship...tr
dc.identifier.citation...tr
dc.identifier.doi10.1016/j.molstruc.2022.134536en_US
dc.identifier.endpage1282tr
dc.identifier.issue1tr
dc.identifier.scopus2-s2.0-85142883615en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage1274tr
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0022286022021810?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14374
dc.identifier.volume1274tr
dc.identifier.wosWOS:000904519000002en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJournal of Molecular Structuretr
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectChitosan, Breast cancer cell, Doxorubucin, Drug delivery, Molecular dockingtr
dc.titleDoxorubucin loaded pH-responsive chitosan-poly(acrylamide-maleic acid) composite hydrogel for anticancer targetingen_US
dc.typeArticleen_US

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