Anticancer, Antioxidant, Antimicrobial and Enzyme Inhibitory Activities of Inula aucheriana

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dc.authoridBOZTEPE GUCLU, GULSEN/0000-0002-3599-213X
dc.authoridUcar, Esra/0000-0001-6327-4779
dc.authoridAtas, Mehmet/0000-0002-9425-0080
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authoridAkpulat, Huseyin Askin/0000-0001-8394-2746
dc.contributor.authorGuclu, Gulsen
dc.contributor.authorErgul, Merve
dc.contributor.authorUcar, Esra
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAtas, Mehmet
dc.contributor.authorAkpulat, Huseyin Askin
dc.date.accessioned2024-10-26T18:00:35Z
dc.date.available2024-10-26T18:00:35Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe Inula aucheriana, of the Asteraceae family, is widespread in Turkey. The aim of this study was to investigate different biological properties and thereby reveal the pharmacological potential of this plant, which is already known to be used in the treatment of various diseases,. Following the preparation of 80% ethanol extract from I. aucheriana, qualitative and quantitative methods were used to investigate the chemical composition (Q-TOF analysis), antioxidant (spectrophotometric analysis), inhibitory enzyme (Ellman's method), antimicrobial (MIC concentration value), and anti-cancer (XTT analysis) activities. The results showed that 80% ethanol extract from I. aucheriana was a potent antioxidant, with anti-cancer and enzyme inhibitor effects. In the chemical composition analysis, the primary compound of the extract was determined to be luteolin (32.55%). I. aucheriana extract was seen to have AChE and BChE inhibition, , and when compared with the reference drug, the extract was determined to have an inhibitory effect an enzyme called alpha-glucosidase. Besides, relatively high tyrosinase enzyme inhibition was also detected. The extract significantly showed antiproliferative activity on the MDA-MB-231 cells at 0.0625 mg/mL and higher concentrations,for 24 hours in a a dose-dependent manner.This study is the first to evaluate enzyme inhibitory effect and antioxidant activity of I. aucheriana.
dc.identifier.doi10.18016/ksutarimdoga.vi.985837
dc.identifier.endpage954
dc.identifier.issn2619-9149
dc.identifier.issue5
dc.identifier.startpage946
dc.identifier.trdizinid1133336
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.985837
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1133336
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27763
dc.identifier.volume25
dc.identifier.wosWOS:000869734700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKahramanmaras Sutcu Imam Univ Rektorlugu
dc.relation.ispartofKsu Tarim ve Doga Dergisi-Ksu Journal of Agriculture and Nature
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInula aucheriana
dc.subjectAnticancer
dc.subjectAntioxidant
dc.subjectEnzyme Inhibitory
dc.subjectMedicinal and Aromatic Plants
dc.titleAnticancer, Antioxidant, Antimicrobial and Enzyme Inhibitory Activities of Inula aucheriana
dc.typeArticle

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