Effects of Mebendazole on the Caspase-mediated Apoptosis mechanism in Cancer cell culture

Basit Öğe Kaydı
dc.authoridKARA, Haki/0000-0002-0295-0582
dc.authoridSAHIN, MAHMUT/0000-0003-3765-748X
dc.contributor.authorSahin, Mahmut
dc.contributor.authorKara, Haki
dc.date.accessioned2024-10-26T18:02:12Z
dc.date.available2024-10-26T18:02:12Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study was conducted to compare Mebendazole in terms of its apoptosis-inducing and tubulin-inhibitory effects when combined with vincristine and paclitaxel, both of which are used in cancer treatment. Lung fibroblast cells (MRC-5) and small cell lung carcinoma (NCI-H209) cell lines were used in the study. Concentrations of Mebendazole, vincristine, and paclitaxel at 0.5 pM, 1 pM, 1.5 pM, and 2 pM were separately applied to these cell lines, as well as in combinations. After the cells were kept in the culture medium for 24 hours following drug administration, cell proliferation, apoptotic DNA levels, caspase 3, 8, and 9 levels, and in vitro wound healing experiments were performed. It was determined that Mebendazole suppressed cell proliferation and cell healing, increased caspase-3, caspase-8, caspase-9 levels and apoptotic DNA formation in NCI- H209 cancer lung cells. Compared to the groups given Mebendazole and vincristine alone, it was observed that cell proliferation was more suppressed and, the level of apoptosis increased in cancerous cells in the groups given the combination of the two drugs. According to the findings obtained from the present study, it was believe that Mebendazole may possess therapeutic activity against cancerous lung cells (NCI-H209) due to its apoptosis-inducing and cell proliferation- suppressive effects.
dc.description.sponsorshipCumhuriyet University Scientific Research Projects Coordination Unit (CUBAP, Sivas, Turkey ) [V-065]
dc.description.sponsorshipThis work was supported by Cumhuriyet University Scientific Research Projects Coordination Unit (CUBAP, Sivas, Turkey, grant number: V-065).
dc.identifier.doi10.52973/rcfcv-e34367
dc.identifier.issn0798-2259
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85193006995
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.52973/rcfcv-e34367
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28011
dc.identifier.volume34
dc.identifier.wosWOS:001216661700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Zulia, Facultad Ciencias Veterinarias
dc.relation.ispartofRevista Cientifica-Facultad De Ciencias Veterinarias
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectanti-cancer
dc.subjectMebendazole
dc.subjectPaclitaxel
dc.subjectVincristine
dc.titleEffects of Mebendazole on the Caspase-mediated Apoptosis mechanism in Cancer cell culture
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu