The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway

Basit Öğe Kaydı
dc.authoridOzdemir, Ercan/0000-0001-8231-1053
dc.authoridTaskiran, Ahmet Sevki/0000-0002-5810-8415
dc.contributor.authorDemirkazik, Ayse
dc.contributor.authorOzdemir, Ercan
dc.contributor.authorArslan, Gokhan
dc.contributor.authorTaskiran, Ahmet Sevki
dc.contributor.authorPelit, Aykut
dc.date.accessioned2024-10-26T18:09:51Z
dc.date.available2024-10-26T18:09:51Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThere is growing interest in the effects of extremely low-frequency electromagnetic fields on mechanisms in biological organisms. This study's goal is to determine the role of the Nitiric Oxide (NO) pathway for thermal pain by intentionally interfering with it using a pulsed electromagnetic field generated by an extremely low frequency alternating current (ELF-PEMF) in combination with BAY41-2272 (sGC activator), NOS inhibitor L-NAME, and NO donor L-arginine. This study included 72 adult male Wistar albino rats (mean weight of 230 +/- 12 g). The rats were kept at room temperature (22 +/- 2 degrees C) in a 12-h light/dark cycle and in a room with sound insulation. PEMF (50 Hz, 5 mT) were applied four times a day for 30 min and at 15-min intervals for 15 days. Analgesic effects were assessed with tail-flick and hot-plate tests. Before the tests, NO donor L-arginine (300 mg/kg), sGC activator BAY41-2272 (10 mg/kg), and NOS inhibitor L-name (40 mg/kg) were injected intraperitoneally into rats in six randomly-selected groups. The maximum analgesic effect of a 5 mT electromagnetic field was on day 7. PEMF significantly increased the analgesia effect when the functioning of the NO pathway was ensured with L-arginine, which is a NO donor, and BAY41-2271, which is the intracellular receptor and sGC activator. However, there was no difference between rats treated with PEMF and the NOS inhibitor L-NAME as compared to rats only treated with PEMF. In conclusion, PEMF generate analgesia by activating the NO pain pathway.
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Project [T-629]; (CUBAP, Turkey)
dc.description.sponsorshipThis study was funded by Sivas Cumhuriyet University Scientific Research Project (T-629, CUBAP, Turkey).
dc.identifier.doi10.1016/j.niox.2019.08.003
dc.identifier.endpage54
dc.identifier.issn1089-8603
dc.identifier.issn1089-8611
dc.identifier.pmid31408675
dc.identifier.scopus2-s2.0-85070879743
dc.identifier.scopusqualityQ2
dc.identifier.startpage49
dc.identifier.urihttps://doi.org/10.1016/j.niox.2019.08.003
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30298
dc.identifier.volume92
dc.identifier.wosWOS:000488144400007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofNitric Oxide-Biology and Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElectromagnetic field
dc.subjectAnalgesia
dc.subjectNitric oxide pathway
dc.subjectRats
dc.titleThe effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu