Role of interferon regulatory factors in predicting the prognosis of Crimean-Congo hemorrhagic fever

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dc.authoridZararsiz, Gokmen/0000-0001-5801-1835
dc.authoridBUYUKTUNA, SEYIT ALI/0000-0001-6518-7361
dc.authoridDOGAN, Halef Okan/0000-0001-8738-0760
dc.contributor.authorOksuz, Caner
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorZararsiz, Gokmen
dc.contributor.authorElaldi, Nazif
dc.contributor.authorBuyuktuna, Seyit Ali
dc.date.accessioned2025-05-04T16:45:56Z
dc.date.available2025-05-04T16:45:56Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives Crimean-Congo hemorrhagic fever (CCHF) is a severe viral illness with a high fatality rate. The interferon response plays a crucial role in the antiviral defense against the CCHF virus (CCHFV). Interferon regulatory factors (IRFs) are essential for initiating and amplifying the interferon response. In this study, we aimed to evaluate the IRF response in CCHF patients for the first time.Methods This study investigated the expression levels of various IRFs (IRF-1, 2, 3, 4, and 7) in CCHF patients and evaluated their potential association with disease prognosis. The research encompassed a cohort of 60 CCHF patients and 30 healthy volunteers. CCHF was diagnosed with CCHFV positivity using PCR method and/or IgM detection using ELISA method. The quantitative sandwich ELISA technique was employed to determine the levels of serum IRF-1, IRF-2, IRF-3, IRF-4, IRF-7, interferon (IFN)-alpha, and IFN-beta.Results There were statistically significant differences in the levels of serum IRF-1, IRF-2, IRF-3, IRF-4, IRF-7, IFN-alpha, and IFN-beta between the patient and healthy control groups. Patients showed elevated levels in all these factors except for IRF-1. However, no statistically significant differences were found in IRF-1, IRF-2, IRF-3, IRF-4, IRF-7, IFN-alpha, and IFN-beta levels between patients who survived and those who died.Conclusions IFN-alpha and beta likely contribute to the immune response in CCHF. IRF-2, 3, 4, and 7 play crucial roles in IFN-alpha and beta expression, pivotal for the antiviral response in CCHF. Targeted interventions to modulate IRF-1 could alleviate disease severity and overall impact.
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects Coordination Unit [T-2021-920]
dc.description.sponsorshipWe would like to thank Sivas Cumhuriyet University Scientific Research Projects Coordination Unit for providing financial support to our study with the project number T-2021-920.
dc.identifier.doi10.1515/tjb-2024-0271
dc.identifier.endpage107
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105001650767
dc.identifier.scopusqualityQ3
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.1515/tjb-2024-0271
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35290
dc.identifier.volume50
dc.identifier.wosWOS:001372979700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectinterferon
dc.subjectviral disease
dc.subjectCrimean-Congo hemorrhagic fever
dc.subjectinterferon regulatory factor
dc.subjectviral pathogenesis
dc.titleRole of interferon regulatory factors in predicting the prognosis of Crimean-Congo hemorrhagic fever
dc.typeArticle

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