Evaluation of cytokines as Th1/Th2 markers in pathogenesis of children with Crimean-Congo hemorrhagic fever

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dc.contributor.authorSancakdar, Enver
dc.contributor.authorGuven, Ahmet Sami
dc.contributor.authorUysal, Elif Bilge
dc.contributor.authorKaya, Ali
dc.contributor.authorDeveci, Koksal
dc.contributor.authorKarapinar, Hekim
dc.contributor.authorAkkar, Ismail
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:00Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:00Z
dc.date.issued2014
dc.department[Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Med Biochem, TR-58140 Sivas, Turkey -- [Guven, Ahmet Sami -- Kaya, Ali] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Akkar, Ismail] Sivas State Hosp, Dept Pediat, Sivas, Turkeyen_US
dc.description.abstractCytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in children with CCHF. Fifty-two patients diagnosed with CCHF and 34 healthy controls (HC) were included in the study. The patients with CCHF were divided into two groups (severe and non-severe). The levels of the Interleukin-10 (IL-10), IL-12, IL-6, Endothelin-1 (ET-1) and tumor necrosis factor-alpha (TNF-alpha) were measured in all groups. IL-12 levels did not show any difference between the CCHF and HC groups and among the severe, non-severe and HC groups. IL-10 and ET-1 levels were significantly higher in the severe group when compared to the non-severe group and the HC group. Moreover, IL-10 and ET-1 levels were significantly higher in the non-severe group when compared to the HC group. In terms of IL-6 and TNF-alpha levels, there was no difference between the severe and non-severe groups while the said levels were significantly higher in the severe group when compared to the HC group. The results of the present study showing significantly higher IL-10 and ET-1 levels in the severe group suggest that Th2-mediated humoral immunity is more effective in the pathogenesis and severity of CCHF in children.en_US
dc.identifier.endpage757en_US
dc.identifier.issn1940-5901
dc.identifier.issue3en_US
dc.identifier.pmid24753773en_US
dc.identifier.scopus2-s2.0-84897553902en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage751en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8418
dc.identifier.volume7en_US
dc.identifier.wosWOS:000336739100035en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-CENTURY PUBLISHING CORPen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectIL-10en_US
dc.subjectIL-12en_US
dc.subjectET-1en_US
dc.subjectTh2en_US
dc.titleEvaluation of cytokines as Th1/Th2 markers in pathogenesis of children with Crimean-Congo hemorrhagic feveren_US
dc.typeArticleen_US

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