Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma

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dc.authoridAlakus, Huseyin/0000-0003-2650-7208
dc.authorid/0000-0002-1807-6957
dc.authoridMollaoglu, Mukadder/0000-0002-9264-3059
dc.contributor.authorAlakus, Huseyin
dc.contributor.authorKaya, Mustafa
dc.contributor.authorMollaoglu, Murat Can
dc.contributor.authorGoksu, Mustafa
dc.contributor.authorOzer, Hatice
dc.contributor.authorKaradayi, Kursat
dc.date.accessioned2024-10-26T18:09:25Z
dc.date.available2024-10-26T18:09:25Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: To investigate the association between the ratio of negative/positive lymph nodes ( RNP) and other clinic pathological parameters. Study Design: Descriptive study. Place and Duration of Study: Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to December 2019. Methodology: Consecutive 119 patients with gastric adenocarcinoma, who underwent gastrectomy and D2 lymph node dissection, were included. RNP, other clinicopathological parameters such as tumour grade, type and lymphovascular invasion (LVI) were analysed, as their prognostic impact was investigated. Results: RNP was an independent prognostic factor for overall survival (p = 0.003) and was significantly associated with poor survival (p <0.001). Advanced pathologic T and N stage, presence of perineural invasion (PNI), presence of LVI, high tumour grade, and diffuse-type as per Louren's classification, and the number of the negative lymph nodes were also significantly associated with poor survival (all p <0.05). Although pathologic N stage (p <0.01), PNI (p <0.01), LVI (p <0.01), tumour type as per Louren's classification (p <0.01), tumour grade (p <0.01) and the number of negative lymph nodes (p <0.01) were significantly associated with overall survival in univariate analyses; only gender (p = 0.025), gastrectomy type (p = 0.037), PNI (p = 0.028), tumour type (p = 0.006), and number of negative lymph nodes (p = 0.003) were meaningfully associated with survival in a multivariate analysis. Conclusion: The ratio of negative/positive lymph nodes can be used as an independent prognostic marker in patients with gastric cancer, who undergo curative resection, as an alternative prognostic marker to the pathologic N stage.
dc.identifier.doi10.29271/jcpsp.2021.07.805
dc.identifier.endpage810
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue7
dc.identifier.pmid34271780
dc.identifier.scopus2-s2.0-85111234848
dc.identifier.scopusqualityQ3
dc.identifier.startpage805
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2021.07.805
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30079
dc.identifier.volume31
dc.identifier.wosWOS:000672588300010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherColl Physicians & Surgeons Pakistan
dc.relation.ispartofJcpsp-Journal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStomach neoplasms
dc.subjectLymph node ratio
dc.subjectPrognosis
dc.subjectGastrectomy
dc.subjectLymph nodes
dc.titleNegative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma
dc.typeArticle

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