Toxicological investigation of bisphenol A and its derivates on human breast epithelial (MCF-10A) cells

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dc.authoridKaptaner, Burak/0000-0003-2366-6756
dc.contributor.authorBakan, Buket
dc.contributor.authorKaptaner, Burak
dc.contributor.authorTokmak, Merve
dc.contributor.authorAykut, Handan
dc.contributor.authorMendil, Ali Sefa
dc.contributor.authorOzkaraca, Mustafa
dc.date.accessioned2025-05-04T16:46:59Z
dc.date.available2025-05-04T16:46:59Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBisphenols can enter the body, where they have potential adverse effects on human health, via different routes such as inhalation, dermally or orally. They are known as endocrine disrupting chemicals that activate signaling pathways by mimicking the estrogen actions. In this study, we aimed to investigate effects of bisphenol A (BPA), and its analogues bisphenol F (BPF) and bisphenol S (BPS) on MCF-10A cells and their impact mechanisms on autophagy, apoptosis and reduced glutathion levels. In comparison of the cytotoxic effects, while BPF and BPS showed dose-dependent high toxicity on MCF-10A cells, BPA exerted cytotoxic effects only at the highest doses. Caspase 3 and LC3B are strongly and positively correlated with BPF exposures while significant changes were not detected in the BPA and BPS applied groups. It was clearly observed that BPF and BPS displayed more toxic effects than BPA on human breast cells that are important targets for the bisphenols. These findings provide data for understanding the mechanisms for BPA, BPF and BPS-induced toxicity on human breast cells.
dc.identifier.doi10.1016/j.tiv.2024.106004
dc.identifier.issn0887-2333
dc.identifier.issn1879-3177
dc.identifier.pmid39736419
dc.identifier.scopus2-s2.0-85213849839
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.tiv.2024.106004
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35441
dc.identifier.volume104
dc.identifier.wosWOS:001398990200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofToxicology in Vitro
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectBisphenols
dc.subjectIn vitro toxicity
dc.subjectImmunofluorescence
dc.subjectMCF-10 A
dc.titleToxicological investigation of bisphenol A and its derivates on human breast epithelial (MCF-10A) cells
dc.typeArticle

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